Ligand (D)-4-hydroxy-alpha-ketoglutarate

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Basic Ligand Information

Molecular Structure
Picture of (D)-4-hydroxy-alpha-ketoglutarate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H6O6
(D)-4-hydroxy-alpha-ketoglutarate
WXSKVKPSMAHCSG-UWTATZPHSA-N
Synonyms:
(4R)-4-hydroxy-2-oxoglutarate, D-4-hydroxy-2-oxoglutarate, R-4-hydroxy-2-oxo-1,5-pentanedioate, S-4-hydroxy-2-oxo-1,5-pentanedioate
Pathway Source
Pathways
BRENDA
gluconeogenesis
KEGG
Arginine and proline metabolism
MetaCyc
trans-4-hydroxy-L-proline degradation I


Show all pahtways known for Show all BRENDA pathways known for (D)-4-hydroxy-alpha-ketoglutarate

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
D-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate
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show the reaction diagram
(4R)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate
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Product in Enzyme-catalyzed Reactions (5 results)

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EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
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show the reaction diagram
L-erythro-4-hydroxyglutamate + 2-oxoglutarate = D-4-hydroxy-2-oxoglutarate + L-glutamate
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show the reaction diagram
pyruvate + glyoxylate = D-4-hydroxy-2-oxoglutarate
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show the reaction diagram
D,L-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate + D-4-hydroxy-2-oxoglutarate
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Enzyme Kinetic Parameters

KM Value (6 results)

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COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
pH 8.3, 37°C
0.031
-
pH 8.1, 25°C
25
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References & Links

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Links to other databases for (D)-4-hydroxy-alpha-ketoglutarate

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ChEBI
PubChem
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PubChem