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Ligand procollagen 5-hydroxy-L-lysine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.50

UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine

737134, 725955

-

2.4.1.50

UDPgalactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine

489280, 439149

-

2.4.1.50

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.4

procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2

-

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.50

UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine

737134, 725955

-

2.4.1.50

UDPgalactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine

439149, 489281, 489279, 489282, 489280, 489285, 489284, 489283

-

2.4.1.50

2 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.4

procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2

-

-

Enzyme Kinetic Parameters

References & Links

Literature References (10)

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Show Reference (10 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

439149

6210830

Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes

1982

Kivirikko, K.I.; Myllylä, R.

Methods Enzymol.

82

245-304

489279

5722225

Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen

1968

Bosmann, H.B.; Eylar, E.H.

Biochem. Biophys. Res. Commun.

33

340-346

489280

5167576

Characterization of membrane-bound collagen galactosyltransferase of human blood platelets

1971

Barber, A.J.; Jamieson, G.A.

Biochim. Biophys. Acta

252

546-552

489281

938472

Partial purification and characterization of collagen galactosyltransferase from chick embryos

1976

Risteli, L.; Myllylä, R.; Kivirikko, K.I.

Biochem. J.

155

145-153

489282

6458240

Collagen glucosyl- and galactosyltransferases of cultured human fetal lung fibroblasts

1981

Carnicero, H.H.; Adamany, A.M.; Englard, S.

Arch. Biochem. Biophys.

210

678-690

489283

986940

Affinity chromatography of collagen glycosyltransferases on collagen linked to agarose

1976

Risteli, L.; Myllylä, R.; Kivirikko, K.I.

Eur. J. Biochem.

67

197-202

489284

629745

Further characterization of collagen galactosyltransferase from chick embryos

1978

Risteli, L.

Biochem. J.

169

189-196

489285

1236138

Assay of collagen-galactosyltransferase and collagen-glucosyltransferase activities and preliminary characterization of enzymic reactions with transferases from chick-embryo cartilage

1975

Myllylä, R.; Risteli, L.; Kivirikko, K.I.

Eur. J. Biochem.

52

401-410

725955

23378577

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

2013

Gilkes, D.M.; Bajpai, S.; Wong, C.C.; Chaturvedi, P.; Hubbi, M.E.; Wirtz, D.; Semenza, G.L.

Mol. Cancer Res.

11

456-466

737134

25419660

Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin

2014

Risteli, M.; Ruotsalainen, H.; Bergmann, U.; Venkatraman Girija, U.; Wallis, R.; Myllylae, R.

PLoS ONE

9

e113498

Links to other databases for procollagen 5-hydroxy-L-lysine

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Show Links (1 entry)