Ligand N-Methyl-2-oxoglutaramate
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Basic Ligand Information
Molecular Structure

C6H9NO4
N-Methyl-2-oxoglutaramate
MOIJYNHJLPUMNX-UHFFFAOYSA-N
2-Oxoglutarate-5-methylamide, 4-(N-Methylcarbamoyl)-2-oxobutanoate
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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alpha-ketoglutarate + methylamine = N-methyl-2-oxoglutaramate + H2O
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Substrate in Enzyme-catalyzed Reactions (1 result)
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N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine
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Product in Enzyme-catalyzed Reactions (5 results)
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L-glutamylmethylamide + glyoxylate = 2-oxoglutarate-5-methylamide + glycine
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L-glutamylmethylamide + phenylpyruvate = 2-oxoglutarate-5-methylamide + L-phenylalanine
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L-5-N-methylglutamine + glyoxylate = 4-(N-methylcarbamoyl)-2-oxobutanoate + glycine
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L-5-N-methylglutamine + phenylpyruvate = 4-(N-methylcarbamoyl)-2-oxobutanoate + L-phenylalanine
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alpha-ketoglutarate + methylamine = N-methyl-2-oxoglutaramate + H2O
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Enzyme Kinetic Parameters
References & Links
Literature References (2)
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The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid
1969
Hersh, L.B.; Tsai, L.; Stadtman, E.R.
J. Biol. Chem.
244
4677-4683
The glutamine transaminase-omega-amidase pathway
1977
Cooper, A.J.L.; Meister, A.
CRC Crit. Rev. Biochem.
4
281-303
Links to other databases for N-Methyl-2-oxoglutaramate