Ligand L-hydroxyproline

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of L-hydroxyproline (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H9NO3
L-hydroxyproline
PMMYEEVYMWASQN-BKLSDQPFSA-N
Synonyms:
3-OH-L-Pro, 4-hydroxy-L-Pro, 4-hydroxy-L-proline, 4-hydroxyproline, hydroxy-L-Pro, hydroxy-L-proline, hydroxyproline, Hyp

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thiamine + hydroxyproline = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]4-hydroxypyrrolidine-2-carboxylic acid
show the reaction diagram
-
Hydroxy-L-Pro = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-oxo-proline + NADH = 4-hydroxy-L-proline + NAD+
show the reaction diagram
-
beta-L-arabinofuranosyl-L-hydroxyproline + H2O = beta-L-arabinofuranose + L-hydroxyproline
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydroxy-L-proline + acceptor + H2O = ?
show the reaction diagram
-
acetyl-CoA + 4-hydroxy-L-proline = CoA + N-acetyl-4-hydroxy-L-proline
show the reaction diagram
-
5-L-glutamyl-4-nitroanilide + L-hydroxyproline = 4-nitroaniline + 5-L-glutamyl-L-hydroxyproline
show the reaction diagram
-
thiamine + hydroxyproline = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]4-hydroxypyrrolidine-2-carboxylic acid
show the reaction diagram
-
Hydroxy-L-Pro = ?
show the reaction diagram
-
ATP + 4-hydroxy-L-proline + tRNAPro = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-proline + 2-oxoglutarate + O2 = 4-hydroxyproline + succinate + CO2
show the reaction diagram
-
1-pyrroline-3-hydroxy-5-carboxylate + NAD(P)H = L-hydroxyproline + NAD(P)+
show the reaction diagram
-
3-OH-L-Pro-2-NaI-7-amido-4-carbamoylmethylcoumarin + H2O = 3-OH-L-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
Hyp-Gly + H2O = Hyp + Gly
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
induces KGSADH-III
-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition
-
40 mM, strong
-

3D Structure of Enzyme-Ligand-Complex (PDB) (51 results)

Enzyme Kinetic Parameters

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
6.05
-
in 200 mM Tris-HCl buffer (pH 8.0), at 50°C
400
-
-

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for L-hydroxyproline

ChEBI
PubChem
-
PubChem