Ligand fluoroacetate

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Basic Ligand Information

Molecular Structure
Picture of fluoroacetate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H3FO2
fluoroacetate
QEWYKACRFQMRMB-UHFFFAOYSA-M
Synonyms:
Alpha-fluoroacetate, flouroacetate, fluoroacetic acid, monofluoroacetate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (36 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
fluroracetaldehyde + NAD+ + H2O = fluoroacetate + NADH
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (37 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + fluoroacetate + CoA = AMP + diphosphate + fluoroacetyl-CoA
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ethyl fluoroacetate + H2O = ethanol + fluoroacetate
show the reaction diagram
-
-
fluoroacetamide + H2O = fluoroacetate + NH3
show the reaction diagram
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-
2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-fluoroacetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-acetamido-2-deoxy-D-glucose + H2O = GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNbeta(1-4)GlcNAc + fluoroacetate
show the reaction diagram
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N-(alpha-fluoroacetyl)-Met-Leu-p-nitroanilide + H2O = fluoroacetic acid + Met-Leu-p-nitroanilide
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
hydrolase increases 50-70% by 100 mM fluoroacetate
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2 mM concentration 22% inhibition
-
competitive inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (23 results)

Enzyme Kinetic Parameters

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
31.2
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.246
-
-

References & Links

Links to other databases for fluoroacetate

ChEBI
PubChem
ChEBI
PubChem