Ligand D-histidine

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Basic Ligand Information

Molecular Structure
Picture of D-histidine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H9N3O2
D-histidine
HNDVDQJCIGZPNO-RXMQYKEDSA-N
Synonyms:
D-His
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + D-histidine = CoA + N-acetyl-D-histidine
show the reaction diagram
-
D-histidine = L-histidine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-histidine = D-histidine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-histidine + L-cysteine + O2 = S-(D-histidin-5-yl)-L-cysteine S-oxide + S-(D-histidin-2-yl)-L-cysteine S-oxide + H2O
show the reaction diagram
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D-His + H2O + O2 = 3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
show the reaction diagram
-
D-His + H2O + O2 = ? + H2O2
show the reaction diagram
-
D-histidine + oxidized 2,6-dichloroindophenol + H2O = 3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + reduced 2,6-dichloroindophenol
show the reaction diagram
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acetyl-CoA + D-histidine = CoA + N-acetyl-D-histidine
show the reaction diagram
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S-adenosyl-L-methionine + D-histidine = N-[(3S)-3-amino-3-carboxypropyl]-D-histidine + S-methyl-5'-thioadenosine
show the reaction diagram
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D-histidine = L-histidine
show the reaction diagram
-
ATP + D-histidine + tRNAHis = AMP + diphosphate + D-histidyl-tRNAHis
show the reaction diagram
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ATP + D-His = ADP + phosphate + D-His-D-His
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-histidine = D-histidine
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activating ability in decreasing order: histamine, imidazole, L-histidine, D-histidine
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Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
15 mM, 75% inhibition
-
Ki: 20 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.78
-
pH 8.0, 26°C
1.51
-
pH 8.3, 37°C, recombinant DAO
185.4
-
pH 7.0, 30°C

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.67
-
pH 8.0, 26°C
2.89
-
pH 8.3, 37°C, recombinant DAO
17.26
-
pH 7.0, 30°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.75
-
-
20
-
-

References & Links

Links to other databases for D-histidine

ChEBI
PubChem
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PubChem