We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Ligand 7alpha,27-dihydroxycholesterol Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 7 H4 6 O3
7alpha,27-dihydroxycholesterol
RXMHNAKZMGJANZ-DTTSCKGMSA-N
5-cholestene-3beta,7alpha,27 triol, 7-alpha,27-dihydroxycholesterol, cholest-5-ene-3beta,7alpha,27-triol
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
Substrate in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7alpha,27-dihydroxycholesterol + NAD+ = 7alpha,27-dihydroxy-4-cholesten-3-one + NADH
-
Product in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
Enzyme Kinetic Parameters
KM Value (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
References & Links Literature References (1)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Purification of a 3beta-hydroxy-D5-C27-steroid dehydrogenase from pig liver microsomes active in major and alternative pathways of bile acid biosynthesis
1996
Furster, C.; Zhang, J.; Toll, A.
J. Biol. Chem.
271
20903-20907
Links to other databases for 7alpha,27-dihydroxycholesterol