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Basic Ligand Information
Roles as Enzyme Ligand
Enzyme Kinetic Parameters
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Ligand 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

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Basic Ligand Information

Molecular Structure

Picture of 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate (click for magnification)

Molecular Formula

BRENDA Name

InChIKey

C₉H₁₇O₁₂P

2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

RJDBNSZFZDWPFL-CECBSOHTSA-N

Synonyms:

2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

Pathway Source

Pathways

BRENDA

glycolate and glyoxylate degradation

MetaCyc

glucosylglycerate biosynthesis I, mannosylglucosylglycerate biosynthesis I

Show all BRENDA pathways known for 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.270

GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate = GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

708933

3.1.3.85

2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H2O = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate

750361, 680455

3.1.3.85

2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H2O = 2-O-(alpha-D-glucosyl)-D-glycerate + phosphate

674318

3.1.3.85

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

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EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.226

NDP-glucose + 3-phospho-D-glycerate = NDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

2.4.1.266

UDP-glucose + 3-phospho-D-glycerate = UDP + 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

UDP-glucose + 3-phospho-D-glycerate = UDP + 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

UDP-glucose + 3-phospho-D-glycerate = UDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

UDP-glucose + 3-phospho-D-glycerate = UDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

6 entries

Substrate in Enzyme-catalyzed Reactions (6 results)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.270

ADP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate = ADP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

732910

2.4.1.270

GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate = GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

732910, 708933

2.4.1.270

UDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate = UDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

732910

3.1.3.85

2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H2O = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate

750361, 680455, 674318

3.1.3.85

2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H2O = 2-O-(alpha-D-glucosyl)-D-glycerate + phosphate

2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H2O = ?

708933

Product in Enzyme-catalyzed Reactions (17 results)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.226

NDP-glucose + 3-phospho-D-glycerate = NDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

2.4.1.266

ADP-glucose + 3-phospho-D-glycerate = ADP + 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

ADP-glucose + 3-phospho-D-glycerate = ADP + 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

UDP-glucose + 3-phospho-D-glycerate = UDP + 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

UDP-glucose + 3-phospho-D-glycerate = UDP + 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

ADP-alpha-D-glucose + D-3-phosphoglycerate = ADP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

ADP-alpha-D-glucose + D-3-phosphoglycerate = ADP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

ADP-glucose + 3-phospho-D-glycerate = ADP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

ADP-glucose + 3-phospho-D-glycerate = ADP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

TDP-glucose + 3-phospho-D-glycerate = TDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

TDP-glucose + 3-phospho-D-glycerate = TDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

UDP-glucose + 3-phospho-D-glycerate = UDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5jt0, 3D-view

2.4.1.266

UDP-glucose + 3-phospho-D-glycerate = UDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

5juc, 3D-view

2.4.1.266

16 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (4 entries)

EC NUMBER

ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

K_M Value (15 results)

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Show KM Value (15 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.270

0.41

pH 7.5, 25Â°C

732910

2.4.1.270

0.8

pH 8.5, 60Â°C

708933

3.1.3.85

0.08

pH 7.6, 30Â°C

680455

3.1.3.85

0.1

pH 7.6, 30Â°C

680455

3.1.3.85

0.19

pH 7.0, 70Â°C

674318

3.1.3.85

0.21

pH 7.0, 90Â°C

674318

3.1.3.85

0.27

pH 7.6, 50Â°C

680455

3.1.3.85

0.36

pH 7.0, 70Â°C

674318

3.1.3.85

0.36

pH 7.6, 50Â°C

680455

3.1.3.85

0.41

pH 7.0, 90Â°C

674318

3.1.3.85

0.43

pH 7.0, 85Â°C

674318

3.1.3.85

0.53

pH 7.0, 85Â°C

674318

3.1.3.85

0.79

pH 7.6, 70Â°C

680455

3.1.3.85

1.1

pH 7.6, 90Â°C

2.6

60Â°C, pH 7.0, partially purified enzyme

708933

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

674318

17189358

Glucosylglycerate biosynthesis in the deepest lineage of the bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina

2007

Costa, J.; Empadinhas, N.; da Costa, M.S.

J. Bacteriol.

189

1648-1654

680455

16428406

Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii

2006

Costa, J.; Empadinhas, N.; Goncalves, L.; Lamosa, P.; Santos, H.; da Costa, M.S.

J. Bacteriol.

188

1022-1030

708933

20061481

Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis

2010

Fernandes, C.; Mendes, V.; Costa, J.; Empadinhas, N.; Jorge, C.; Lamosa, P.; Santos, H.; da Costa, M.S.

J. Bacteriol.

192

1624-1633

732910

23921581

Mannosylglucosylglycerate biosynthesis in the deep-branching phylum Planctomycetes: characterization of the uncommon enzymes from Rhodopirellula baltica

2013

Cunha, S.; dAvo, A.F.; Mingote, A.; Lamosa, P.; da Costa, M.S.; Costa, J.

Sci. Rep.

2378

750361

30743161

Identification of glucosyl-3-phosphoglycerate phosphatase as a novel drug target against resistant strain of Mycobacterium tuberculosis (XDR1219) by using comparative metabolic pathway approach

2019

Uddin, R.; Zahra, N.; Azam, S.

Comput. Biol. Chem.

91-102

Links to other databases for 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

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ChEBI

PubChem

Ligand 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

Basic Ligand Information

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

Substrate in Enzyme-catalyzed Reactions (6 results)

Product in Enzyme-catalyzed Reactions (17 results)

3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

Enzyme Kinetic Parameters

KM Value (15 results)

References & Links

Literature References (5)

Links to other databases for 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

K_M Value (15 results)