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Ligand sterol ester

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.43

phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester

0

-

2.3.1.43

phosphatidylcholine + sterol = 1-acylglycerophosphocholine + sterol ester

487009, 486981, 486978

-

2.3.1.43

2 entries

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.43

phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester

0

-

2.3.1.43

phosphatidylcholine + sterol = 1-acylglycerophosphocholine + sterol ester

487011, 487012, 487013, 487014, 487015, 487016, 487017, 487018, 487019, 487021, 487022, 487023, 487024, 487025, 487026, 487027, 486979, 486980, 486985, 486986, 486988, 486992, 486993, 486995, 486996, 486997, 486999, 487000, 487001, 487002, 487003, 487004, 487006, 487007, 487008, 487009, 487005, 486989, 486991, 486976, 486984, 486977, 486978, 486982, 486998, 486981, 486983, 486987, 486994, 487010, 487020, 486990

-

2.3.1.43

2 entries

2.3.1.73

1,2-diacyl-sn-glycerol + sterol = monoacylglycerol + sterol ester

487447, 487448

-

Enzyme Kinetic Parameters

References & Links

Literature References (54)

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Show Reference (54 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

486976

-

Biosynthesis of sterols in Phycomyces blakesleeanus

1974

Bartlett, K.; Keat, M.J.; Mercer, E.I.

Phytochemistry

13

1107-1113

486977

7061477

Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase

1982

Buckley, J.T.; Halasa, L.N.; MacIntyre, S.

J. Biol. Chem.

257

3320-3325

486978

7278683

Lecithin-cholesterol acyltransferase from human plasma

1981

Doi, Y.; Nishida, T.

Methods Enzymol.

71

753-767

486979

7031423

Assay for lecithin: cholesterol acyltransferase

1981

Verdery III, R.B.; Gatt, S.

Methods Enzymol.

72

375-384

486980

3897772

Assay of cholesteryl ester transfer activity and purification of a cholesteryl ester transfer protein

1985

Ogawa, Y.; Fielding, C.J.

Methods Enzymol.

111

274-285

486981

3014276

Isolation, characterization, and assay of lecithin-cholesterol acyltransferase

1986

Albers, J.J.; Chen, C.H.; Lacko, A.G.

Methods Enzymol.

129

763-783

486982

3724553

Mechanisms of action of lecithin-cholesterol acyltransferase

1986

Fielding, C.J.

Methods Enzymol.

129

783-790

486983

1387413

Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 position

1992

Parks, J.S.; Thuren, T.Y.; Schmitt, J.D.

J. Lipid Res.

33

879-887

486984

2824121

Purification of horse (Equus caballus) serum lecithin:cholesterol acyltransferase

1987

Yamamoto, M.; Yamamoto, I.; Tanaka, Y.; Michihiro, S.

Comp. Biochem. Physiol. B

88

363-368

486985

6627099

Characterization of lecithin-cholesterol acyltransferase from human plasma. 3. Chemical properties of the enzyme

1983

Chong, K.S.; Mehrnoosh, J.; Hara, S.; Lacko, A.G.

Can. J. Biochem. Cell Biol.

61

875-881

486986

-

Studies on enzymatic and molecular properties of lecithin:cholesterol acyltransferase

1974

Lacko, A.G.; Varma, K.G.; Rutenberg, H.L.; Soloff, L.A.

Scand. J. Clin. Lab. Invest.

33

29-34

486987

2914888

Human plasma lecithin-cholesterol acyltransferase. Inhibition of the phospholipase A2-like activity by sn-2-difluoroketone phosphatidylcholine analogues

1989

Jauhiainen, M.; Yuan, W.; Gelb, M.H.; Dolphin, P.J.

J. Biol. Chem.

264

1963-1967

486988

1901219

Effects of inhibitors of N-linked oligosaccharide processing on the secretion, stability, and activity of lecithin:cholesterol acyltransferase

1991

Collet, X.; Fielding, C.J.

Biochemistry

30

3228-3234

486989

3080314

Isolation and properties of porcine lecithin:cholesterol acyltransferase

1986

Knipping, G.

Eur. J. Biochem.

154

289-294

486990

701245

Human plasma lecithin-cholesterol acyltransferase. Characterization of cofactor-dependent phospholipase activity

1978

Aron, L.; Jones, S.; Fielding, C.J.

J. Biol. Chem.

253

7220-7226

486991

3718996

Isolation and characterization of lecithin-cholesterol acyltransferase from hog plasma

1986

Park, Y.B.; Lacko, A.G.

Biochim. Biophys. Acta

877

179-190

486992

1770111

Human plasma lecithin:cholesterol acyltransferase. Preparation and use of immobilized p-aminophenylarsenoxide as a catalytic site-directed covalent ligand in enzyme purification

1991

Zhou, G.; Jauhiainen, M.; Stevenson, K.; Dolphin, P.J.

J. Chromatogr.

568

69-83

486993

3523164

Lysolecithin acyltransferase of human plasma: assay and characterization of enzyme activity

1986

Subbaiah, P.V.

Methods Enzymol.

129

790-797

486994

3597406

Inhibition of lecithin-cholesterol acyltransferase by diphytanoyl phosphatidylcholine

1987

Pownall, H.J.; Pao, Q.; Brockman, H.L.; Massey, J.B.

J. Biol. Chem.

262

9033-9036

486995

3888276

A rapid large-scale procedure for purification of lecithin-cholesterol acyltransferase from human and animal plasma

1985

Chen, C.H.; Albers, J.J.

Biochim. Biophys. Acta

834

188-195

486996

6405796

A method for isolating human plasma lecithin:cholesterol acyltransferase without using anti-apolipoprotein D, and its characterization

1983

Mahadevan, V.; Soloff, L.A.

Biochim. Biophys. Acta

752

89-97

486997

949320

A method for the purification of milligram quantities of stable human phosphatidylcholine-cholesterol acyltransferase

1976

Varma, K.G.; Soloff, L.A.

Biochem. J.

155

583-588

486998

222331

Purification of human plasma lecithin:cholesterol acyltransferase and its specificity towards the acyl acceptor

1979

Kitabatake, K.; Piran, U.; Kamio, Y.; Doi, Y.; Nishida, T.

Biochim. Biophys. Acta

573

145-154

486999

6853549

Microheterogeneity and physical properties of human lecithin-cholesterol acyltransferase

1983

Doi, Y.; Nishida, T.

J. Biol. Chem.

258

5840-5846

487000

-

Purification of lecithin-cholesterol acyltransferase from human plasma

1985

Chaves, M.E.C.; Harry, D.S.; Owen, J.; McIntyre, N.

Biochem. Soc. Trans.

13

145-146

487001

6847201

Characterization of lecithin:cholesterol acyltransferase from human plasma: II. Physical properties of the enzyme

1983

Chong, K.S.; Hara, S.; Thompson, R.E.; Lacko, A.G.

Arch. Biochem. Biophys.

222

553-560

487002

7305362

Characterization of lecithin: cholesterol acyltransferase from human plasma: purification of the enzyme

1981

Chong, K.S.; Davidson, L.; Huttash, R.G.; Lacko, A.G.

Arch. Biochem. Biophys.

211

119-124

487003

7448618

Purification of human plasma lecithin:cholesterol acyltransferase and its activation by metal ions

1980

Suzue, G.; Vezina, C.; Marcel, Y.L.

Can. J. Biochem.

58

539-541

487004

7214196

Stereochemical substrate requirements of lecithin:cholesterol acyltransferase and its inhibition by enantiomeric lysolecithins

1980

Smith, N.B.; Kuksis, A.

Can. J. Biochem.

58

1286-1291

487005

2475485

Isolation and properties of rat plasma lecithin-cholesterol acyltransferase

1989

Furukawa, Y.; Urano, T.; Itoh, H.; Takahashi, C.; Kimura, S.

J. Biochem.

105

962-967

487006

222760

Stability and properties of lecithin-cholesterol acyltransferase

1979

Furukawa, Y.; Nishida, T.

J. Biol. Chem.

254

7213-7219

487007

457692

Isolation, properties, and mechanism of in vitro action of lecithin: cholesterol acyltransferase from human plasma

1979

Chung, J.; Abano, D.A.; Fless, G.M.; Scanu, A.M.

J. Biol. Chem.

254

7456-7464

487008

1252427

Purification and characterization of human plasma lecithin: cholesterol acyltransferase

1976

Albers, J.J.; Cabana, V.G.; De Barden Stahl, Y.

Biochemistry

15

1084-1087

487009

8016111

Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase

1994

Liu, M.; Subbaiah, P.V.

Proc. Natl. Acad. Sci. USA

91

6035-6039

487010

11111093

Lecithin cholesterol acyltransferase

2000

Jonas, A.

Biochim. Biophys. Acta

1529

245-256

487011

8504148

Activation of plasma lysolecithin acyltransferase reaction by apolipoproteins A-I, C-I and E

1993

Liu, M.; Subbaiah, P.V.

Biochim. Biophys. Acta

1168

144-152

487012

8379944

Lecithin:cholesterol acyltransferase: Role of N-linked glycosylation in enzyme function

1993

O, K.; Hill, J.S.; Wang, X.; McLeod, R.; Pritchard, P.H.

Biochem. J.

294

879-884

487013

9059515

Analysis of human lecithin-cholesterol acyltransferase activity by carboxyl-terminal truncation

1997

Lee, Y.P.; Adimoolam, S.; Liu, M.; Subbaiah, P.V.; Glenn, K.; Jonas, A.

Biochim. Biophys. Acta

1344

250-261

487014

10685026

Biochemical and compositional analyses of recombinant lecithin:cholesterol acyltransferase (LCAT) obtained from a hepatic source

2000

Ayyobi, A.F.; Lacko, A.G.; Murray, K.; Nair, M.; Li, M.; Molhuizen, H.O.F.; Pritchard, P.H.

Biochim. Biophys. Acta

1484

1-13

487015

10218592

Inhibition of lecithin cholesterol acyltransferase by phosphatidylcholine hydroperoxides

1999

Davit-Spraul, A.; Therond, P.; Leroy, A.; Palmade-Rieunier, F.; Rousset, C.; Moatti, N.; Legrand, A.

FEBS Lett.

447

106-110

487016

27280993

Substrate specificity of rat plasma lecithin-cholesterol acyltransferase towards a molecular species of phosphatidylcholine

1993

Hida, Y.; Furukawa, Y.; Urano, T.; Kim, H.J.; Kimura, S.

Biosci. Biotechnol. Biochem.

57

1111-1114

487017

9125178

Activation of lecithin cholesterol acyltransferase by a disulfide-linked apolipoprotein A-I dimer

1997

Calabresi, L.; Franceschini, G.; Burkybile, A.; Jonas, A.

Biochem. Biophys. Res. Commun.

232

345-349

487018

10828089

Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease

2000

Demeester, N.; Castro, G.; Desrumaux, C.; De Geitere, C.; Fruchart, J.C.; Santens, P.; Mulleners, E.; Engelborghs, S.; De Deyn, P.P.; Vandekerckhove, J.; Rosseneu, M.; Labeur, C.

J. Lipid Res.

41

963-974

487019

8364023

Effects of site-directed mutagenesis on the N-glycosylation sites of human lecithin:cholesterol acyltransferase

1993

Qu, S.J.; Fan, H.Z.; Blanco-Vaca, F.; Pownall, H.J.

Biochemistry

32

8732-8736

487020

7947733

Role of sn-2 acyl group of phosphatidyl choline in determining the positional specificity of lecithin-cholesterol acyltransferase

1994

Subbaiah, P.V.; Liu, M.; Paltauf, F.

Biochemistry

33

13259-13266

487021

10744775

Phosphatidylcholine fluidity and structure affect lecithin:cholesterol acyltransferase activity

2000

Parks, J.S.; Huggins, K.W.; Gebre, A.K.; Burleson, E.R.

J. Lipid Res.

41

546-553

487022

9555945

Characterization of recombinant human plasma lecithin: cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties

1998

Lacko, A.G.; Reason, A.J.; Nuckolls, C.; Kudchodkar, B.J.; Nair, M.P.; Sundarrajan, G.; Pritchard, P.H.; Morris, H.R.; Dell, A.

J. Lipid Res.

39

807-820

487023

10428989

Characterization of C-terminal histidine-tagged human recombinant lecithin:cholesterol acyltransferase

1999

Chisholm, J.W.; Gebre, A.K.; Parks, J.S.

J. Lipid Res.

40

1512-1519

487024

9215537

Biochemical and biophysical characterization of human recombinant lecithin: cholesterol acyltransferase

1997

Jin, L.; Lee, Y.P.; Jonas, A.

J. Lipid Res.

38

1085-1093

487025

9179288

Purification of recombinant lecithin: cholesterol acyltransferase

1997

Nair, M.P.; Kudchodkar, B.J.; Pritchard, P.H.; Lacko, A.G.

Protein Expr. Purif.

10

38-41

487026

11435418

Interaction of lecithin:cholesterol acyltransferase (LCAT).a2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an a2-macroglobulin/LRP receptor-mediated system participating in LCAT clearance

2001

Krimbou, L.; Marcil, M.; Davignon, J.; Genest, J.Jr.

J. Biol. Chem.

276

33241-33248

487027

9829992

Structural and functional properties of two mutants of lecithin-cholesterol acyltransferase (T123I and N228K)

1998

Adimoolam, S.; Jin, L.; Grabbe, E.; Shieh, J.J.; Jonas, A.

J. Biol. Chem.

273

32561-32567

487447

-

1,2-Diacyl-sn-glycerol: sterol acyl transferase from spinach leaves (Spinacia olerecea L.)

1981

Garcia, R.E.; Mudd, J.B.

Methods Enzymol.

71

768-772

487448

742884

Metabolism of monoacylglycerol and diacylglycerol by enzyme preparations from spinach leaves

1978

Garcia, R.E.; Mudd, J.B.

Arch. Biochem. Biophys.

191

487-493

Links to other databases for sterol ester

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Show Links (1 entry)