Ligand beta-cyclodextrin

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Basic Ligand Information

Molecular Structure
Picture of beta-cyclodextrin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C42H70O35
beta-cyclodextrin
WHGYBXFWUBPSRW-FOUAGVGXSA-N
Synonyms:
beta-cyclomaltodextrin, beta cyclodextrin, cycloheptaamylose, cyclomaltoheptaose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
beta-cyclodextrin + H2O = maltooligosaccharide
show the reaction diagram
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beta-cyclodextrin + H2O = maltose + D-glucose
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (58 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
beta-cyclodextrin = ?
show the reaction diagram
-
maltose + beta-cyclodextrin = 6-O-alpha-maltosyl-beta-cyclodextrin
show the reaction diagram
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ATP + beta-cyclodextrin + H2O = AMP + phospho-beta-cyclodextrin + phosphate
show the reaction diagram
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beta-cyclodextrin + H2O = maltotriose
show the reaction diagram
-
beta-cyclodextrin + H2O = maltose + D-glucose
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (88 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
beta-cyclodextrin + H2O = beta-cyclodextrin + beta-D-glucose
show the reaction diagram
-
-
pullulan + H2O = panose + beta-cyclodextrin
show the reaction diagram
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di-O-alpha-maltosyl-beta-cyclodextrin + H2O = maltose + beta-cyclodextrin
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates GDE in liver
-
9% increased activity at 1 mM
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Inhibitor in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
20% residual activity at a substrate/cyclodextrin molar ratio of 0.5
-
1 mM,inhibition
-
mixed-type competitive inhibition, the inhibitor can be accomodated in the glycogen storage site of T-state enzyme, subsite specificity
-
a mixed-type inhibitor
-
competitive inhibitor, 0.025%
-
competitive inhibitor
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3D Structure of Enzyme-Ligand-Complex (PDB) (28 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (51 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.11
-
pH 3.5, 95°C
1.37
-
pH 6.5, 85°C, recombinant enzyme

KM Value (60 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
5.16
-
pH 3.5, 95°C
14.53
-
pH 6.5, 85°C, recombinant enzyme

Ki Value (9 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
14.1
-
with respect to glycogen
0.0556
-
pH 5.5, 75°C, recombinant His-tagged enzyme
0.41
-
pH 9, 50°C, 0.025%

References & Links

Links to other databases for beta-cyclodextrin

ChEBI
PubChem
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PubChem