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Ligand indole-3-methanol

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.13.99.3

3-indolemethanol + ferricyanide = ?

439312

-

1.13.99.3

3-indolemethanol + O2 = ?

439304, 439312, 439313

-

1.13.99.3

2 entries

Inhibitor in Enzyme-catalyzed Reactions (4 results)

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Show Inhibitors (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.13.99.3

inhibits oxidation of skatole

439312

-

1.14.13.8

and its acid condensation products, strong

348502

-

1.14.13.8

competitive inhibition of FMO3

703320

-

1.14.13.8

2 entries

1.8.1.B1

inhibit the enzyme in a NADPH-dependent manner, and the inhibition appears to be irreversible even upon extensive dilution of the inhibited protein

763814

-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

1.8.1.9

6zlb, 3D-view

Enzyme Kinetic Parameters

K_M Value (5 results)

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Show KM Value (5 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.13.99.3

0.0435

-

-

439313

1.13.99.3

0.0435

-

TSO I

439304

1.13.99.3

0.055

-

cosubstrate O2

439313

1.13.99.3

0.055

-

TSO II

439304

1.13.99.3

0.48

-

-

439312

1.13.99.3

5 entries

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.13.8

0.008

0.013

-

348502

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

348502

10509757

In vitro and in vivo inhibition of human flavin-containing monooxygenase form 3 (FMO3) in the presence of dietary indoles

1999

Cashman, J.R.; Xiong, Y.; Lin, J.; Verhagen, H.; van Poppel, G.; van Bladeren, P.J.; Larsen-Su, S.; Williams, D.

Biochem. Pharmacol.

58

1047-1055

439304

3037258

Purification and properties of tryptophan side chain oxidase types I and II from Pseudomonas

1987

Takai, K.; Hayaishi, O.

Methods Enzymol.

142

195-217

439312

500674

Isolation and reconstitution of two electron transfer components of tryptophan side chain oxidase

1979

Ushiro, H.; Takai, K.; Narumiya, S.; Ito, S.; Hayaishi, O.

J. Biol. Chem.

254

11794-11797

439313

721824

Tryptophan side chain oxidase from Pseudomonas. Oxidation of skatole to indole-3-carboxaldehyde via indole-3-methanol

1978

Ushiro, H.; Takai, K.; Noda, Y.; Narumiya, S.; Tokuyama, T.; Hayaishi, O.

J. Biol. Chem.

253

9002-9008

703320

18473746

Flavin mono-oxygenase (FMO) - The other oxidase

2008

Mitchell, S.

Curr. Drug Metab.

9

280-284

763814

33950676

Probing the surface of a parasite drug target thioredoxin glutathione reductase using small molecule fragments

2021

Fata, F.; Silvestri, I.; Ardini, M.; Ippoliti, R.; Di Leandro, L.; Demitri, N.; Polentarutti, M.; Di Matteo, A.; Lyu, H.; Thatcher, G.R.J.; Petukhov, P.A.; Williams, D.L.; Angelucci, F.

ACS Infect. Dis.

7

1932-1944

Links to other databases for indole-3-methanol

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Show Links (1 entry)

ChEBI

PubChem