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Ligand gentamicin A Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 8 H3 6 N4 O1 0
gentamicin A
LKKVGKXCMYHKSL-LLZRLKDCSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + gentamicin A = diphosphate + 2''-adenylylgentamicin A
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Substrate in Enzyme-catalyzed Reactions (4 results)
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S-adenosyl-L-methionine + gentamicin A = S-adenosyl-L-homocysteine + ?
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acetyl-CoA + gentamicin A = CoA + N3'-acetylgentamicin A
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acetyl-CoA + gentamicin A = CoA + N3'-acetylgentamicin A
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ATP + gentamicin A = diphosphate + 2''-adenylylgentamicin A
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
References & Links Literature References (5)
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Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor
1971
Benveniste, R.; Davies, J.
Biochemistry
10
1787-1796
Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa
1982
Angelatou, F.; Litsas, S.B.; Kontomichalou, P.
J. Antibiot.
35
235-244
Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values
1978
Williams, J.W.; Northrop, D.B.
J. Biol. Chem.
253
5908-5914
Alternative substrate and inhibition kinetics of aminoglycoside nucleotidyltransferase 2''-I in support of a Theorell-Chance kinetic mechanism
1988
Gates, C.A.; Northrop, D.B.
Biochemistry
27
3826-3833
Reaction catalyzed by GenK, a cobalamin-dependent radical S-adenosyl-L-methionine methyltransferase in the biosynthetic pathway of gentamicin, proceeds with retention of configuration
2017
Kim, H.J.; Liu, Y.N.; McCarty, R.M.; Liu, H.W.
J. Am. Chem. Soc.
139
16084-16087
Links to other databases for gentamicin A
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