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Ligand gamma-Glu-L-Cys(S-propyl)-Gly

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.17.3

S-propyl-glutathione + ascorbate + O2 = S-propyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O

657649

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2.3.2.15

S-propylglutathione + [Glu(-Cys)]n-Gly = Gly + [Glu(-Cys)]n-Glu-S-propyl-Cys-Gly

487893

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6.3.1.8

gamma-Glu-L-Cys(S-propyl)-Gly + spermidine + ATP = N1-(gamma-Glu-L-Cys(S-propyl)-Gly)-spermidine + ADP + phosphate

966

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Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.151

propylcobalamin + [alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + S-propyglutathione

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2.5.1.18

glutathione + 1-iodopropane = iodide + propyl-glutathione

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Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.2

-

660108

-

3.1.2.6

-

664268

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Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

6.3.1.8

8.7

-

-

966

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.17.3

0.11

-

pH 6.0, 37°C

657649

6.3.1.8

0.53

-

-

966

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.2.2

0.0679

-

-

660108

3.1.2.6

1.9

-

25°C

664268

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

966

9041518

Characterization of the peptide substrate specificity of glutathionylspermidine synthetase from Crithidia fasciculata

1997

De Craecker, S.; Verbruggen, C.; Rajan, P.; Smith, K.; Haemers, A.; Fairlamb, A.H.

Mol. Biochem. Parasitol.

84

25-32

487893

10807919

Mechanism of heavy metal ion activation of phytochelatin (PC) synthase: blocked thiols are sufficient for PC synthase-catalyzed transpeptidation of glutathione and related thiol peptides

2000

Vatamaniuk, O.K.; Mari, S.; Lu, Y.P.; Rea, P.A.

J. Biol. Chem.

275

31451-31459

657649

12646261

Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase

2003

Miller, L.A.; Baumgart, L.E.; Chew, G.H.; deLong, M.A.; Galloway, L.C.; Jung, K.W.; Merkler, K.A.; Nagle, A.S.; Poore, D.D.; Yoon, C.H.; Merkler, D.J.

Arch. Biochem. Biophys.

412

3-12

660108

15721943

Purification and cloning of a gamma-glutamyl transpeptidase from onion (Allium cepa)

2005

Shaw, M.L.; Pither-Joyce, M.D.; McCallum, J.A.

Phytochemistry

66

515-522

664268

15843146

Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts

2005

Akoachere, M.; Iozef, R.; Rahlfs, S.; Deponte, M.; Mannervik, B.; Creighton, D.J.; Schirmer, H.; Becker, K.

Biol. Chem.

386

41-52

Links to other databases for gamma-Glu-L-Cys(S-propyl)-Gly

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Show Links (1 entry)

ChEBI

PubChem

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