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Ligand gamma-Glu-L-Cys(S-ethyl)-Gly

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.17.3

S-ethyl-glutathione + ascorbate + O2 = S-ethyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O

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2.3.2.15

S-ethylglutathione + [Glu(-Cys)]n-Gly = Gly + [Glu(-Cys)]n-Glu-S-ethyl-Cys-Gly

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6.3.1.8

gamma-Glu-L-Cys(S-ethyl)-Gly + spermidine + ATP = N1-(gamma-Glu-L-Cys(S-ethyl)-Gly)-spermidine + ADP + phosphate

966

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Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.151

ethylcobalamin + [alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + S-ethylglutathione

0

-

2.5.1.18

glutathione + 1-iodoethane = iodide + ethylglutathione

0

-

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

7.6.2.2

supports transport of vincristine

210388

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Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

6.3.1.8

11.3

-

-

966

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.17.3

0.23

-

pH 6.0, 37°C

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6.3.1.8

0.18

-

-

966

References & Links

Literature References (4)

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Show Reference (4 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

966

9041518

Characterization of the peptide substrate specificity of glutathionylspermidine synthetase from Crithidia fasciculata

1997

De Craecker, S.; Verbruggen, C.; Rajan, P.; Smith, K.; Haemers, A.; Fairlamb, A.H.

Mol. Biochem. Parasitol.

84

25-32

210388

9823323

Characterization of vincristine transport by the Mr 190000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione

1998

Loe, D.W.; Deeley, R.G.; Cole, S.P.C.

Cancer Res.

58

5130-5136

487893

10807919

Mechanism of heavy metal ion activation of phytochelatin (PC) synthase: blocked thiols are sufficient for PC synthase-catalyzed transpeptidation of glutathione and related thiol peptides

2000

Vatamaniuk, O.K.; Mari, S.; Lu, Y.P.; Rea, P.A.

J. Biol. Chem.

275

31451-31459

657649

12646261

Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase

2003

Miller, L.A.; Baumgart, L.E.; Chew, G.H.; deLong, M.A.; Galloway, L.C.; Jung, K.W.; Merkler, K.A.; Nagle, A.S.; Poore, D.D.; Yoon, C.H.; Merkler, D.J.

Arch. Biochem. Biophys.

412

3-12

Links to other databases for gamma-Glu-L-Cys(S-ethyl)-Gly

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Show Links (1 entry)

ChEBI

PubChem

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