Ligand UDP-mannose

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Basic Ligand Information

Molecular Structure
Picture of UDP-mannose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H24N2O17P2
UDP-mannose
HSCJRCZFDFQWRP-NYYOCOOHSA-N
Synonyms:
alpha-UDP-mannose, UDP-alpha-D-mannopyranose, UDP-alpha-D-mannose, UDP-D-mannose, UDP-Man, UDPmannose, UDP mannose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDPmannose + diphosphate = UTP + D-mannose 1-phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-alpha-D-mannose + 2 NAD+ + H2O = UDP-alpha-D-mannuronate + 2 NADH + 2 H+
show the reaction diagram
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UDP-Man + Galbeta(1-3)Gal = Manbeta(1-3)Galbeta(1-3)Gal + UDP
show the reaction diagram
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UDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate = UDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
show the reaction diagram
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UDP-mannose + quercetin = UDP + quercetin 3-O-beta-D-mannoside
show the reaction diagram
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UDPmannose + diphosphate = UTP + D-mannose 1-phosphate
show the reaction diagram
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UDP-mannose + phosphate = UDP + D-mannose 1-phosphate
show the reaction diagram
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diphosphate + UDP-mannose = UTP + D-mannose 1-phosphate
show the reaction diagram
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UDP-mannose + H2O = UMP + D-mannose 1-phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UTP + D-mannose 1-phosphate = diphosphate + UDP-mannose
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak inhibition
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1 mM, about 20% inhibition
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50% of inhibition at 40 uM
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competitive, 61% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
-999
-
kcat value is not detected, in 100 mM cacodylate buffer, pH 7.0 containing 10 mM MnCl2 and 0.2-6 microM purified fusion-beta1,4-GalT7

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
-999
-
KM value is not detected, in 100 mM cacodylate buffer, pH 7.0 containing 10 mM MnCl2 and 0.2-6 microM purified fusion-beta1,4-GalT7
0.074
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pH 5.0, 37°C, mutant enzyme H308R
0.25
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pH 8.0, 30°C

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
-999
-
Ki value is above 9, UDP-galactose 0.1-16 mM, 0-10 mM UDP-mannose

References & Links

Links to other databases for UDP-mannose

ChEBI
PubChem
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PubChem