Ligand P53

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Basic Ligand Information

Molecular Structure
Picture of P53 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C75H119N29O26R2S2
P53
FXDNYOANAXWZHG-VKHMYHEASA-N

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + p53 = ?
show the reaction diagram
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acetyl-CoA + p53 = CoA + acetyl-p53
show the reaction diagram
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NAD+ + p53 = nicotinamide + (ADP-D-ribosyl)-p53
show the reaction diagram
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ATP + p53 = ADP + phosphorylated p53
show the reaction diagram
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ATP + p53 = ADP + phosphorylated p53
show the reaction diagram
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ATP + p53 = ADP + phospho-p53
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphorylated p53 + H2O = p53 + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + p53 = ?
show the reaction diagram
-
acetyl-CoA + p53 = CoA + acetyl-p53
show the reaction diagram
-
NAD+ + p53 = nicotinamide + (ADP-D-ribosyl)-p53
show the reaction diagram
-
ATP + p53 = ADP + phosphorylated p53
show the reaction diagram
-
p53 + ATP = phosphorylated-p53 + ADP
show the reaction diagram
-
ATP + p53 = ADP + phosphorylated p53
show the reaction diagram
-
ATP + p53 = ADP + phospho-p53
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphorylated p53 + H2O = p53 + phosphate
show the reaction diagram
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P53 precursor + H2O = P53
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates, required
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POX is a p53-induced gene
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p53 activates DGKalpha in response to DNA damage
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p53 induces PIDD expression resulting in a feed-forward loop
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2
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down-regulation of enzyme expression, possibly contributes to the dysregulation of the enzyme observed in cancer
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after camptothecin treatment, p53 is a negative regulator of APE1 expression, APE1 promoter activity is repressed by wild-type p53, but not by mutant p53
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Enzyme Kinetic Parameters

References & Links

Links to other databases for P53

ChEBI
PubChem
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PubChem