Ligand 4-hydroxyglutamate
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Basic Ligand Information
C5H9NO5
4-hydroxyglutamate
HBDWQSHEVMSFGY-UHFFFAOYSA-N
2-amino-4-hydroxyglutarate, 2-amino-4-hydroxyglutaric acid, D,L-gamma-hydroxyglutamate
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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D,L-gamma-hydroxyglutamate = ?
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Product in Enzyme-catalyzed Reactions (2 results)
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DELTA1-pyrroline-3-hydroxy-5-carboxylate + NAD+ + H2O = 4-hydroxyglutamate + NADH
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L-asparagine + 4-hydroxy-2-oxoglutarate = 2-oxosuccinamate + 2-amino-4-hydroxyglutarate
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
Ki Value (1 result)
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References & Links
Literature References (4)
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The optically-specific enzymatic cyclization of D-glutamate
1963
Meister, A.; Bukenberger, M.W.; Strassburger, M.
Biochem. Z.
338
217-229
Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from DELTA1-pyrroline-3-hydroxy-5-carboxylate
1960
Adams, E.; Goldstone, A.
J. Biol. Chem.
235
3504-3512
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Enzymology of pyrrolidone carboxylic acid
1971
Orlowski, M.; Meister, A.
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
123-151
Inhibitors of glutamine synthetase and their potential application in medicine
2008
Berlicki, L.
Mini Rev. Med. Chem.
8
869-878
Links to other databases for 4-hydroxyglutamate