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Ligand Z-Gly-Pro

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.22.B60

Z-Gly-Pro-Gly-Gly-Pro-Ala + H2O = Z-Gly-Pro + Gly-Gly + L-Pro-L-Ala

0

-

3.4.22.B60

Z-Gly-Pro-Leu-Gly-Pro + H2O = Z-Gly-Pro + L-Leu + Gly + L-Pro

0

-

3.4.22.B60

2 entries

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.16.5

benzyloxycarbonyl-Gly-Pro + H2O = benzyloxycarbonyl-Gly + Pro

647195

-

Product in Enzyme-catalyzed Reactions (69 results)

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Show Product (69 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.16.2

N-benzyloxycarbonyl-Gly-L-Pro 4-nitroanilide + H2O = N-benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline

0

-

3.4.16.2

N-benzyloxycarbonyl-Gly-Pro-Phe + H2O = N-benzyloxycarbonyl-Gly-Pro + Phe

0

-

3.4.16.2

2 entries

3.4.17.16

Benzyloxycarbonyl-Gly-Pro-Ala + H2O = Benzyloxycarbonyl-Gly-Pro- + Ala

28890

-

3.4.21.26

benzyloxycarbonyl-Gly-L-Pro-2-naphthylamide + H2O = benzyloxycarbonyl-Gly-L-Pro + 2-naphthylamine

0

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O = benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline

0

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O = benzyloxycarbonyl-Gly-L-Pro + 7-amino-4-methylcoumarin

0

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-L-Pro-doxorubicin + H2O = benzyloxycarbonyl-Gly-L-Pro + doxorubicin

0

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-L-Pro-melphalan + H2O = benzyloxycarbonyl-Gly-L-Pro + melphalan

0

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-2-naphthylamide + H2O = benzyloxycarbonyl-Gly-Pro + 2-naphthylamine

653857, 0

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O = benzyloxycarbonyl-Gly-Pro + 7-amino-4-methylcoumarin

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O = benzyloxycarbonyl-Gly-Pro + 4-nitroaniline

0

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-4-nitrophenyl ester + H2O = benzyloxycarbonyl-Gly-Pro + 4-nitrophenol

0

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-Ala + H2O = benzyloxycarbonyl-Gly-Pro + Ala

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O = benzyloxycarbonyl-Gly-Pro + 2-naphthylamine

0, 652332

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O = benzyloxycarbonyl-Gly-Pro + beta-naphthylamine

653873, 652324, 652483

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-D-Ala + H2O = benzyloxycarbonyl-Gly-Pro + D-Ala

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-D-Leu + H2O = benzyloxycarbonyl-Gly-Pro + D-Leu

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-Leu + H2O = benzyloxycarbonyl-Gly-Pro + Leu

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-Leu-Ala + H2O = benzyloxycarbonyl-Gly-Pro + Leu-Ala

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-Leu-D-Ala + H2O = benzyloxycarbonyl-Gly-Pro + Leu-D-Ala

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O = benzyloxycarbonyl-Gly-Pro + Leu-Gly

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-Leu-Gly-Ala + H2O = benzyloxycarbonyl-Gly-Pro + Leu-Gly-Ala

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-Leu-Gly-D-Ala + H2O = benzyloxycarbonyl-Gly-Pro + Leu-Gly-D-Ala

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-Leu-Gly-Gly + H2O = benzyloxycarbonyl-Gly-Pro + Leu-Gly-Gly

653873

1e8m, 3D-view

3.4.21.26

Benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro + H2O = Benzyloxycarbonyl-Gly-Pro + Leu-Gly-Pro

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O = benzyloxycarbonyl-Gly-Pro + p-nitroaniline

652752, 649523, 653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-p-nitrophenol + H2O = benzyloxycarbonyl-Gly-Pro + p-nitrophenol

653873, 652332

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-Phe + H2O = benzyloxycarbonyl-Gly-Pro + Phe

653873

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-SBzl + H2O = benzyloxycarbonyl-Gly-Pro + phenyl-methanethiol

652332

1e8m, 3D-view

3.4.21.26

benzyloxycarbonyl-Gly-Pro-thiobenzyl ester + H2O = benzyloxycarbonyl-Gly-Pro + phenylmethanethiol

0

1e8m, 3D-view

3.4.21.26

N-benzyloxycarbonyl-Gly-Pro-4-nitrophenyl ester + H2O = N-benzyloxycarbonyl-Gly-Pro + 4-nitrophenol

0

1e8m, 3D-view

3.4.21.26

N-carbobenzoxy-Gly-L-Pro-7-amido-4-methylcoumarin + H2O = N-carbobenzoxy-Gly-L-Pro + 7-amino-4-methylcoumarin

0

1e8m, 3D-view

3.4.21.26

N-carbobenzyloxy-glycyl-proline-4-methyloumarin-7-amide + H2O = N-carbobenzyloxy-glycyl-proline + 7-amino-4-methylcoumarin

0

1e8m, 3D-view

3.4.21.26

Z-Gly-L-Pro-4-nitroanilide + H2O = Z-Gly-L-Pro + 4-nitroaniline

0

1e8m, 3D-view

3.4.21.26

Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O = Z-Gly-L-Pro + 7-amino-4-methylcoumarin

0

1e8m, 3D-view

3.4.21.26

Z-Gly-Pro-2-naphthylamide + H2O = Z-Gly-Pro + 2-naphthylamine

0

1e8m, 3D-view

3.4.21.26

Z-Gly-Pro-4-nitroanilide + H2O = 4-nitroaniline + Z-Gly-Pro

0

1e8m, 3D-view

3.4.21.26

Z-Gly-Pro-4-nitroanilide + H2O = Z-Gly-Pro + 4-nitroaniline

0

1e8m, 3D-view

3.4.21.26

Z-Gly-Pro-4-nitroanilide + H2O = Z-Gly-Pro + p-nitroaniline

0

1e8m, 3D-view

3.4.21.26

Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O = Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin

0

1e8m, 3D-view

3.4.21.26

Z-Gly-Pro-7-amido-4-methylcoumarin + H2O = z-Gly-Pro + 7-amino-4-methylcoumarin

0

1e8m, 3D-view

3.4.21.26

Z-Gly-Pro-7-amido-4-methylcoumarin = Z-Gly-Pro + 7-amino-4-methylcoumarin

0

1e8m, 3D-view

3.4.21.26

Z-Gly-Pro-p-nitroanilide + H2O = Z-Gly-Pro + p-nitroaniline

0

1e8m, 3D-view

3.4.21.26

Z-Gly-Pro-4-nitroanilide + H2O = Z-glycyl-L-proline + 4-nitroaniline

0

1e8m, 3D-view

3.4.21.27

benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O = benzyloxycarbonyl-Gly-Pro + 4-nitroaniline

0

-

3.4.21.27

benzyloxycarbonyl-Gly-Pro-p-nitroanilide = benzyloxycarbonyl-Gly-Pro + p-nitroaniline

0

-

3.4.21.B28

benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O = benzyloxycarbonyl-Gly-L-Pro + 7-amino-4-methylcoumarin

0

-

3.4.21.B28

benzyloxycarbonyl-Gly-Pro-7-amido-4-methyl-3-carbamoylcoumarin + H2O = benzyloxycarbonyl-Gly-Pro + 7-amino-4-methyl-3-carbamoylcoumarin

0

-

3.4.21.B28

benzyloxycarbonyl-Gly-Pro-7-amido-4-methylcoumarin + H2O = benzyloxycarbonyl-Gly-Pro + 7-amino-4-methylcoumarin

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-7-amido-4-methylcoumarin + H2O = N-benzyloxycarbonyl-Gly-Pro + 7-amino-4-methylcoumarin

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Ala + H2O = N-benzyloxycarbonyl-Gly-Pro + L-Ala

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Glu + H2O = N-benzyloxycarbonyl-Gly-Pro + L-Glu

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-His + H2O = N-benzyloxycarbonyl-Gly-Pro + L-His

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Leu + H2O = N-benzyloxycarbonyl-Gly-Pro + L-Leu

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Met + H2O = N-benzyloxycarbonyl-Gly-Pro + L-Met

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Met-His + H2O = N-benzyloxycarbonyl-Gly-Pro + Met-His

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Met-His-Arg-Ser + H2O = N-benzyloxycarbonyl-Gly-Pro + Met-His-Arg-Ser

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Phe + H2O = N-benzyloxycarbonyl-Gly-Pro + L-Phe

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Phe-His + H2O = N-benzyloxycarbonyl-Gly-Pro + L-Phe-L-His

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Phe-His-Arg + H2O = N-benzyloxycarbonyl-Gly-Pro + Phe-His-Arg

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Phe-His-Arg-Ser + H2O = N-benzyloxycarbonyl-Gly-Pro + Phe-His-Arg-Ser

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Ser + H2O = N-benzyloxycarbonyl-Gly-Pro + L-Ser

0

-

3.4.21.B28

N-benzyloxycarbonyl-Gly-Pro-Tyr + H2O = N-benzyloxycarbonyl-Gly-Pro + L-Tyr

0

-

3.4.21.B28

Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O = Z-Gly-L-Pro + 7-amino-4-methylcoumarin

0

-

3.4.22.B60

Z-Gly-Pro-Gly-Gly-Pro-Ala + H2O = Z-Gly-Pro + Gly-Gly + L-Pro-L-Ala

0

-

3.4.22.B60

Z-Gly-Pro-Leu-Gly-Pro + H2O = Z-Gly-Pro + L-Leu + Gly + L-Pro

0

-

3.4.22.B62

Z-Gly-Pro-Gly-Gly-Pro-Ala + H2O = Z-Gly-Pro + Gly + Gly + L-Pro-L-Ala

0

-

3.4.22.B62

Z-Gly-Pro-Leu-Gly-Pro + H2O = Z-Gly-Pro + L-Leu + Gly + L-Pro

0

-

3.4.21.26

41 entries

3.4.21.27

2 entries

3.4.21.B28

18 entries

3.4.22.B60

2 entries

3.4.22.B62

2 entries

3.4.24.53

Benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro + H2O = Benzyloxycarbonyl-Gly-Pro + Leu-Gly-Pro

31297

-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

3.4.21.26

1e8m, 3D-view

Enzyme Kinetic Parameters

References & Links

Literature References (10)

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Show Reference (10 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

28890

5500406

The cleavage of prolyl peptides by kidney peptidases. Isolation of a microsomal carboxypeptidase from swine kidney

1970

Dehm, P.; Nordwig, A.

Eur. J. Biochem.

17

372-377

31297

4984550

Purification and characterization of a proteinase in the venom of Trimeresurus flavoviridis. Complete separation of the enzyme from hemorrhagic activity

1970

Takahashi, T.; Ohsaka, A.

Biochim. Biophys. Acta

198

293-307

647195

13269

Carboxypeptidase Y

1976

Hayashi, R.

Methods Enzymol.

45

568-587

649523

11534759

Prolyl endopeptidase inhibitors from green tea

2001

Kim, J.H.; Kim, S.I.; Song, K.S.

Arch. Pharm. Res.

24

292-296

652324

12202494

Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site

2002

Szeltner, Z.; Rea, D.; Renner, V.; Fulop, V.; Polgar, L.

J. Biol. Chem.

277

42613-42622

652332

12228249

Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase

2002

Szeltner, Z.; Rea, D.; Juhasz, T.; Renner, V.; Mucsi, Z.; Orosz, G.; Fulop, V.; Polgar, L.

J. Biol. Chem.

277

44597-44605

652483

14514675

Electrostatic environment at the active site of prolyl oligopeptidase is highly influential during substrate binding

2003

Szeltner, Z.; Rea, D.; Renner, V.; Juliano, L.; Fulop, V.; Polgar, L.

J. Biol. Chem.

278

48786-48793

652752

14521416

New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides

2003

Wallen, E.A.; Christiaans, J.A.; Jarho, E.M.; Forsberg, M.M.; Venalainen, J.I.; Mannisto, P.T.; Gynther, J.

J. Med. Chem.

46

4543-4551

653857

11495689

Effects of hydrosaline treatments on prolyl endopeptidase activity in rat tissues

2001

Irazusta, J.; Silveira, P.F.; Gil, J.; Varona, A.; Casis, L.

Regul. Pept.

101

141-147

653873

-

Proline-specific endopeptidases

2003

Besedin, D.V.; Rudenskaya, G.N.

Russ. J. Bioorg. Chem.

29

1-17

Links to other databases for Z-Gly-Pro

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Show Links (1 entry)

ChEBI

PubChem