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Ligand 2-Hydroxypyridine Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C5 H5 NO
2-Hydroxypyridine
UBQKCCHYAOITMY-UHFFFAOYSA-N
2-pyridone, dihydropyridin-2-one, pyridol
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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2-hydroxypyridine + NADH + O2 = 2,5-dihydroxypyridine + NAD+ + H2O
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Substrate in Enzyme-catalyzed Reactions (1 result)
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2-hydroxypyridine + NADH + O2 = 2,5-dihydroxypyridine + NAD+ + H2O
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Product in Enzyme-catalyzed Reactions (2 results)
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pyridyl 3-sulfate + H2O = pyridol + sulfate
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pyridyl 4-sulfate + H2O = pyridol + sulfate
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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48% inhibition at 0.1 mM, reversible inhibitor
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3D Structure of Enzyme-Ligand-Complex (PDB) (5 results)
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Enzyme Kinetic Parameters
References & Links Literature References (3)
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Metabolism of 2-hydroxypyridine by Bacillus brevis (INA)
1984
Sharma, M.L.; Kaul, S.M.; Shukla, O.P
Biol. Mem.
9
43-52
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase
2001
Baitsch, D.; Sandu, C.; Brandsch, R.; Igloi, G.L.
J. Bacteriol.
183
5262-5267
Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: A cis-prenyltransferase for bacterial peptidoglycan biosynthesis
2012
Teng, K.; Liang, P.
Bioorg. Chem.
43
51-57
Links to other databases for 2-Hydroxypyridine