Ligand 5-fluorouridine

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Basic Ligand Information

Molecular Structure
Picture of 5-fluorouridine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H11FN2O6
5-fluorouridine
FHIDNBAQOFJWCA-UAKXSSHOSA-N
Synonyms:
5-fluoro-uridine
Pathway Source
Pathways

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-fluorouridine + phosphate = 5-fluorouracil + alpha-D-ribose 1-phosphate
show the reaction diagram
-
5-fluorouridine + H2O = D-ribose + 5-fluorouracil
show the reaction diagram
-
5-fluorouridine + H2O = 5-fluorouracil + D-ribose
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-fluoro-dUMP + H2O = 5-fluoro-uridine + phosphate
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak
-
competitive
-
the combination of 0.3 mM zeatin with the protein inhibitor results in the alleviation of their inhibitory effect on the urease activity
-

3D Structure of Enzyme-Ligand-Complex (PDB) (6 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
6.1
-
pH 7.6, 37°C
14.7
-
pH 7.3, 37°C

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.047
-
pH 7.6, 37°C
0.024
-
pH 7.4, 37°C
1.3
-
pH 8.0, 37°C
0.128
-
pH 7.3, 37°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.6
-
pH 7.5, 37°C, wild-type enzyme, versus uridine

References & Links

Links to other databases for 5-fluorouridine

ChEBI
PubChem
ChEBI
PubChem