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Ligand 3-methyladenine
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Basic Ligand Information
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open all tablesRoles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (5 results)
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EC NUMBER 
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alkylated DNA + H2O = 3-methyladenine + ?
alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
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alkylated DNA + H2O = 7-methyladenine + 7-methylguanine + 3-methyladenine + 3-methylguanine + purine + 6-chloropurine + xanthine + DNA
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Product in Enzyme-catalyzed Reactions (17 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alkylated DNA + H2O = 3-methyladenine + ?
alkylated DNA + H2O = 3-methyladenine + 3-methylguanine + 7-methyladenine + 7-methylguanine + DNA
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alkylated DNA + H2O = 3-methyladenine + 3-methylguanine + 7-methylguanine + 7-methyladenine + ?
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + 1,N6-ethenoadenine + hypoxanthine + DNA
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
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alkylated DNA + H2O = 7-methyladenine + 7-methylguanine + 3-methyladenine + 3-methylguanine + purine + 6-chloropurine + xanthine + DNA
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Activator in Enzyme-catalyzed Reactions (1 result)
Inhibitor in Enzyme-catalyzed Reactions (7 results)
EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
treatment in full medium for a prolonged period of time leads to marked increases of the autophagic markers in cells. The increase of autophagic markers is the result of enhanced autophagic flux. The autophagy promotion activity is due to its differential temporal effects on class I and class III PI3K enzymes. 3-Methyladenine blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient. Treatment with 3-methyladenine in full medium significantly reduces the level of phosphatidylinositol 3-phosphate, the product of class III PI3K, at early time points, but almost completely blocks the product of phosphatidylinositol 3,4,5-trisphosphate up to 9 h
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treatment in full medium for a prolonged period of time leads to marked increases of the autophagic markers in cells. The increase of autophagic markers is the result of enhanced autophagic flux. The autophagy promotion activity is due to its differential temporal effects on class I and class III PI3K enzymes. 3-Methyladenine blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient. Treatment with 3-methyladenine in full medium significantly reduces the level of phosphatidylinositol 3-phosphate, the product of class III PI3K, at early time points, but almost completely blocks the product of phosphatidylinositol 3,4,5-trisphosphate up to 9 h
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)
Enzyme Kinetic Parameters
Ki Value (1 result)
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
IC50 Value (2 results)
EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
References & Links
Literature References (28)
Links to other databases for 3-methyladenine
ChEBI
PubChem
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Release 2023.1 (January 2023)
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