Ligand Epitestosterone

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Basic Ligand Information

Molecular Structure
Picture of Epitestosterone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H28O2
Epitestosterone
MUMGGOZAMZWBJJ-KZYORJDKSA-N
Synonyms:
(17alpha)-17-hydroxyandrost-4-en-3-one, 4-androsten-17alpha-ol-3-one, 17-epitestosterone, 17alpha-Hydroxy-4-androsten-3-one, 17alpha-hydroxyandrosten-3-one

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
17alpha-hydroxy-4-androsten-3-one + NADP+ = 4-androsten-3,17-dione + NADPH
show the reaction diagram
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epitestosterone + NADP+ = 4-androsten-3,17-dione + NADPH + H+
show the reaction diagram
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epitestosterone + NAD(P)+ = ?
show the reaction diagram
epitestosterone + NADPH + H+ = ?
show the reaction diagram
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3'-phosphoadenylylsulfate + epitestosterone = adenosine 3',5'-bisphosphate + epitestosterone sulfate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
androstenedione + NADPH + H+ = epitestosterone + NADP+
show the reaction diagram
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epitestosterone 17-sulfate + H2O = epitestosterone + sulfate
show the reaction diagram
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epitestosterone 17-sulfate + H2O = epitestosterone + sulfate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition for all isoforms at concentration above 0.003 mM, not observed with other substrates
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i.e. epitestosterone
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competitive inhibitor of 17alpha-hydroxylation of pregnenolone and of the subsequent C17,20-side chain cleavage reaction
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3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.1
-
pH 6.0, 37°C

KM Value (17 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0029
-
pH 6.0, 37°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0033
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C

References & Links

Links to other databases for Epitestosterone

ChEBI
PubChem
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PubChem