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Ligand 1-palmitoyl-2-oleoyl-sn-glycerol

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.20

palmitoyl-CoA + sn-2-monooleoylglycerol = CoA + 1-palmitoyl-2-oleoylglycerol

-

-

2.3.1.22

2-monooleoylglycerol + palmitoyl-CoA = 2-oleoyl-3-palmitoylglycerol + CoA

-

-

Substrate in Enzyme-catalyzed Reactions (6 results)

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Show Substrate (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.20

1-palmitoyl-2-oleoyl glycerol + acyl-CoA = 1-palmitoyl-2-oleoyl-3-acylglycerol + CoA

675754

-

2.3.1.20

acyl-CoA + 1-palmitoyl-2-oleoyl-sn-glycerol = CoA + 1-palmitoyl-2-oleoyl-3-acylglycerol

758011

-

2.3.1.20

1-palmitoyl-2-oleoylglycerol + acyl-CoA = 1-palmitoyl-2-oleoyl-3-acylglycerol + CoA

675754

-

2.3.1.20

3 entries

2.7.1.107

ATP + 1-palmitoyl-2-oleoyl-sn-glycerol = ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate

640372, 640357, 640383, 760629

-

2.7.8.1

CDP-ethanolamine + 1-octadecanoyl-2-octadecenoylglycerol = CMP + 1-octadecanoyl-2-octadecenoylglycerophosphoethanolamine

644362

-

2.7.8.2

CDP-choline + 1-palmitoyl-2-oleoyl-sn-glycerol = CMP + 1-palmitoyl-2-oleoyl-sn-glycerophosphocholine

644362

-

Product in Enzyme-catalyzed Reactions (7 results)

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Show Product (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.20

palmitoyl-CoA + sn-2-monooleoylglycerol = CoA + 1-palmitoyl-2-oleoylglycerol

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-

2.3.1.22

palmitoyl-CoA + sn-2-monooleoylglycerol = CoA + 1(3)-palmitoyl-2-oleoylglycerol

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-

2.3.1.22

2-monooleoylglycerol + palmitoyl-CoA = 2-oleoyl-3-palmitoylglycerol + CoA

-

-

2.7.8.48

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + 7-nitro-2,1,3-benzoxadiazole-C12-ceramide = 7-nitro-2,1,3-benzoxadiazole-C12-ceramide phosphoethanolamine + 1-palmitoyl-2-oleoyl-sn-glycerol

-

-

2.7.8.48

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + 7-nitro-2,1,3-benzoxadiazole-C6-ceramide = 7-nitro-2,1,3-benzoxadiazole-C6-ceramide phosphoethanolamine + 1-palmitoyl-2-oleoyl-sn-glycerol

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-

2.3.1.22

2 entries

2.7.8.48

2 entries

3.1.4.3

2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine + H2O = 1-palmitoyl-2-oleoyl-sn-glycerol + phosphocholine

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-

3.1.4.62

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-palmitoyl-2-oleoyl-sn-glycerol + O-phosphoethanolamine

-

-

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.8.1

0.167

-

i.e. 1-C18:0,2-C18:1glycerol, 30°C, pH 8.0

644362

2.7.8.2

0.116

-

30°C, pH 8.0

644362

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

640357

2175712

Purification, cDNA-cloning and expression of human diacylglycerol kinase

1990

Schaap, D.; de Widt, J.; van der Wal, J.; Vandekerckhove, J.; van Damme, J.; Gussow, D.; Ploegh, H.L.; van Blitterswijk, W.J.; van der Bend, R.L.

FEBS Lett.

275

151-158

640372

-

Diacylglycerol lipase and kinase activities in rat brain microvessels

1985

Hee-Cheong, M.; Fletcher, T.; Kryski, S.K.; Severson, D.L.

Biochim. Biophys. Acta

883

59-68

640383

8626588

Molecular cloning and characterization of a novel human diacylglycerol kinase zeta

1996

Bunting, M.; Tang, W.; Zimmerman, G.A.; McIntyre, T.M.; Prescott, S.M.

J. Biol. Chem.

271

10230-10236

644362

209025

Acyl chain length dependency of diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase. Effect of different saturated fatty acids at the C-1 or C-2 position of diacylglycerol on solubilized rat liver microsomal enzymes

1978

Morimoto, K.; Kanoh, H.

J. Biol. Chem.

253

5056-5060

675754

17269553

Diacylglycerol acyltransferase: a key mediator of plant triacylglycerol synthesis

2006

Lung, S.C.; Weselake, R.J.

Lipids

41

1073-1088

758011

26919811

Characterization of type 2 diacylglycerol acyltransferases in Chlamydomonas reinhardtii reveals their distinct substrate specificities and functions in triacylglycerol biosynthesis

2016

Liu, J.; Han, D.; Yoon, K.; Hu, Q.; Li, Y.

Plant J.

86

3-19

758011

26919811

Characterization of type 2 diacylglycerol acyltransferases in Chlamydomonas reinhardtii reveals their distinct substrate specificities and functions in triacylglycerol biosynthesis

2016

Liu, J.; Han, D.; Yoon, K.; Hu, Q.; Li, Y.

Plant J.

86

3-19

760629

31891772

Diacylglycerol kinase delta destabilizes serotonin transporter protein through the ubiquitin-proteasome system

2020

Lu, Q.; Murakami, C.; Hoshino, F.; Murakami, Y.; Sakane, F.

Biochim. Biophys. Acta

1865

158608

760629

31891772

Diacylglycerol kinase delta destabilizes serotonin transporter protein through the ubiquitin-proteasome system

2020

Lu, Q.; Murakami, C.; Hoshino, F.; Murakami, Y.; Sakane, F.

Biochim. Biophys. Acta

1865

158608

758011

2 entries

760629

2 entries

Links to other databases for 1-palmitoyl-2-oleoyl-sn-glycerol

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Show Links (1 entry)