Ligand 1-methyladenine
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Basic Ligand Information
Molecular Structure
C6H7N5
1-methyladenine
SATCOUWSAZBIJO-UHFFFAOYSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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N1-methyladenine + 2-oxoglutarate + O2 = adenine + formaldehyde + succinate + CO2
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)
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1-methyladenosine + phosphate = 1-methyladenine + alpha-D-ribose 1-phosphate
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1-methyladenosine + H2O = 1-methyladenine + D-ribose
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Substrate in Enzyme-catalyzed Reactions (2 results)
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1-methyladenine + O2 + 2-oxoglutarate = adenine + CO2 + formaldehyde + succinate + H+
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N1-methyladenine + 2-oxoglutarate + O2 = adenine + formaldehyde + succinate + CO2
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Product in Enzyme-catalyzed Reactions (4 results)
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1-methyladenosine + phosphate = 1-methyladenine + alpha-D-ribose 1-phosphate
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1-methyladenosine + H2O = 1-methyladenine + D-ribose
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alkylated DNA + H2O = 1-methyladenine + ?
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1-methyladenosine + H2O = 1-methyladenine + D-ribose
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Enzyme Kinetic Parameters
References & Links
Literature References (6)
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Effect of disulfide-reducing agents on activity of 1-methlyadenosine ribohydrolase in starfish follicle cells
1986
Mita, M.
Dev. Growth Differ.
28
67-74
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1-Methyladenosine hydrolase of starfish (Pisaster ochraceous)
1973
Tarr, H.L.A.
J. Fish. Res. Board Can.
30
1861-1866
1-Methyladenosine ribohydrolase in the starfish ovary and its relation to oocyte maturation
1972
Shirai, H.; Kanani, H.
Exp. Cell Res.
75
79-88
Reversal of DNA alkylation damage by two human dioxygenases
2002
Duncan, T.; Trewick, S.C.; Koivisto, P.; Bates, P.A.; Lindahl, T.; Sedgwick, B.
Proc. Natl. Acad. Sci. USA
99
16660-5
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response
2013
Vagbo, C.B.; Svaasand, E.K.; Aas, P.A.; Krokan, H.E.
DNA Repair
12
188-195
Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB
2012
Li, D.; Delaney, J.C.; Page, C.M.; Yang, X.; Chen, A.S.; Wong, C.; Drennan, C.L.; Essigmann, J.M.
J. Am. Chem. Soc.
134
8896-8901
Links to other databases for 1-methyladenine
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