Ligand ethylenediamine

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Basic Ligand Information

Molecular Structure
Picture of ethylenediamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H8N2
ethylenediamine
DUYYBTBDYZXISX-UKKRHICBSA-N
Synonyms:
1,2-Diaminoethane, Diaminoethane, ethane-1,2-diamine, ethane diamine, ethylene diamine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-diaminoethane + pyruvate = aminoethane + alanine
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + ethylenediamine = CoA + N1-acetyl-ethylenediamine
show the reaction diagram
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1,2-diaminoethane + pyruvate = aminoethane + alanine
show the reaction diagram
-
mesaconate + ethane-1,2-diamine = ?
show the reaction diagram
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ATP + 1,2-diaminoethane + citrate = AMP + diphosphate + 2-[2-[(2-aminoethyl)amino]-2-oxoethyl]-2-hydroxybutandioate
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
supports aminoacylation in presence of crude tRNA not in presence of resolved tRNA
-

Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
complete inhibition at 10 mM
-
10 mM, causes 10-20% inhibition of carboxynorspermidine formation
-
12 mM
-
inhibits Mn2+ stimulation of pNPPase (as well as K+ and Mg2+ stimulation)
-
weak
-
weak
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
7560
-
pH 7.2, 37C

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.196
-
measured at fixed saturating concentrations of acetyl-CoA

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
22
-
-

References & Links

Links to other databases for ethylenediamine

ChEBI
PubChem
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PubChem