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BRENDA support

Ligand (S)-4-hydroxy-2-oxohexanoate

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Basic Ligand Information

Molecular Structure
Picture of (S)-4-hydroxy-2-oxohexanoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H10O4
(S)-4-hydroxy-2-oxohexanoate
ALFQPWXBAWHVDP-BYPYZUCNSA-N
Synonyms:
(4S)-4-hydroxy-2-oxohexanoate
Pathway Source
Pathways
BRENDA
androgen and estrogen metabolism
MetaCyc
4-nitrotoluene degradation II, androstenedione degradation I (aerobic), toluene degradation II (aerobic) (via 4-methylcatechol)


Show all pahtways known for Show all BRENDA pathways known for (S)-4-hydroxy-2-oxohexanoate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate
show the reaction diagram
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(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (3 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyruvate + propionaldehyde = (4S)-4-hydroxy-2-oxohexanoate
show the reaction diagram
-
(2E,4Z)-2-hydroxyhexa-2,4-dienoate + H2O = (4S)-4-hydroxy-2-oxohexanoate
show the reaction diagram
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

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EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.38
-
in 100 mM HEPES (pH 8.0), 1 mM MgCl2, at 25°C

KM Value (1 result)

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EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0048
-
in 100 mM HEPES (pH 8.0), 0.4 mM NADH, 1 mM MgCl2, at 25°C

References & Links

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Links to other databases for (S)-4-hydroxy-2-oxohexanoate

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ChEBI
PubChem
ChEBI
PubChem