Ligand 11beta,21-dihydroxypregn-4-en-3,20-dione

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Basic Ligand Information

Molecular Structure
Picture of 11beta,21-dihydroxypregn-4-en-3,20-dione (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H30O4
11beta,21-dihydroxypregn-4-en-3,20-dione
OMFXVFTZEKFJBZ-KAFNETDFSA-N

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH = 11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH = 11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
potent inhibition of cortisol oxidation
-
11-beta-HSD2, 50% inhibition at 0.00001 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (14 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0000051
-
pH and temperature not specified in the publication

References & Links

Links to other databases for 11beta,21-dihydroxypregn-4-en-3,20-dione

ChEBI
PubChem
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PubChem