Ligand liquiritigenin

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Basic Ligand Information

Molecular Structure
Picture of liquiritigenin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H12O4
liquiritigenin
FURUXTVZLHCCNA-AWEZNQCLSA-N
Synonyms:
(2S)-4',7-dihydroxyflavanone, (2S)-7,4'-dihydroxyflavanone, (2S)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one, (2S)-liquiritigenin, (2S)7,4'-Dihydroxyflavanone

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
liquiritigenin + [reduced NADPH-hemoprotein reductase] + O2 = 7,4'-dihydroxyflavone + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2S)-liquiritigenin + [reduced NADPH-hemoprotein reductase] + O2 = licodione + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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liquiritigenin + [reduced NADPH-hemoprotein reductase] + O2 = 7,4'-dihydroxyflavone + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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liquiritigenin + 2-oxoglutarate + O2 = 7,4'-dihydroxyflavone + succinate + CO2 + H2O
show the reaction diagram
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UDP-glucose + liquiritigenin = UDP + liquiritigenin 7-O-beta-D-glucoside
show the reaction diagram
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UDP-beta-D-glucose + liquiritigenin = UDP + neoliquiritin
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
noncompetitive inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (18 results)

Enzyme Kinetic Parameters

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0042
-
pH 7.9, 25°C

IC50 Value (4 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0468
-
-
0.0628
-
at pH 2.0 and 37°C

References & Links

Links to other databases for liquiritigenin

ChEBI
PubChem
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PubChem