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Ligand N-[[1,1'-bi(cyclohexan)]-4-yl]-6-methoxy-7-[3-(piperidin-1-yl)propoxy]-2-[4-(propan-2-yl)-1,4-diazepan-1-yl]quinazolin-4-amine Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C3 7 H6 0 N6 O2
N-[[1,1'-bi(cyclohexan)]-4-yl]-6-methoxy-7-[3-(piperidin-1-yl)propoxy]-2-[4-(propan-2-yl)-1,4-diazepan-1-yl]quinazolin-4-amine
IEMCIMHNKCYVAG-UHFFFAOYSA-N
Roles as Enzyme Ligand
Inhibitor in Enzyme-catalyzed Reactions (1 result)
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competitive inhibition, the inhibitor docks in the Tudor domain
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Enzyme Kinetic Parameters
IC50 Value (1 result)
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0.0023
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pH and temperature not specified in the publication
References & Links Literature References (1)
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SETDB1, an H3K9-specific methyltransferase An attractive epigenetic target to combat cancer
2024
Prashanth, S.; Radha Maniswami, R.; Rajajeyabalachandran, G.; Jegatheesan, S.K.
Drug Discov. Today
29
103982
Links to other databases for N-[[1,1'-bi(cyclohexan)]-4-yl]-6-methoxy-7-[3-(piperidin-1-yl)propoxy]-2-[4-(propan-2-yl)-1,4-diazepan-1-yl]quinazolin-4-amine