Ligand 7-chloro-2-[3-(dimethylamino)propyl]-1-(3-ethoxyphenyl)-1,2,3a,9a-tetrahydro[1]benzopyrano[2,3-c]pyrrole-3,9-dione
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Basic Ligand Information
C24H27ClN2O4
7-chloro-2-[3-(dimethylamino)propyl]-1-(3-ethoxyphenyl)-1,2,3a,9a-tetrahydro[1]benzopyrano[2,3-c]pyrrole-3,9-dione
SZQSUCWYXKBDQB-UHFFFAOYSA-N
Roles as Enzyme Ligand
Inhibitor in Enzyme-catalyzed Reactions (1 result)
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peptidecompetitive SETDB1 inhibitor, decreases H3K9me3 levels and shows neuronal effects without cytotoxicity
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Enzyme Kinetic Parameters
References & Links
Literature References (1)
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SETDB1, an H3K9-specific methyltransferase An attractive epigenetic target to combat cancer
2024
Prashanth, S.; Radha Maniswami, R.; Rajajeyabalachandran, G.; Jegatheesan, S.K.
Drug Discov. Today
29
103982
Links to other databases for 7-chloro-2-[3-(dimethylamino)propyl]-1-(3-ethoxyphenyl)-1,2,3a,9a-tetrahydro[1]benzopyrano[2,3-c]pyrrole-3,9-dione