Ligand saccharopine

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Basic Ligand Information

Molecular Structure
Picture of saccharopine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C11H20N2O6
saccharopine
ZDGJAHTZVHVLOT-YUMQZZPRSA-N
Synonyms:
6-N-(L-1,3-dicarboxypropyl)-L-lysine, L-saccharopine, N6-(L-1,3-dicarboxypropyl)-L-lysine

Show all pahtways known for Show all BRENDA pathways known for saccharopine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
show the reaction diagram
-
L-saccharopine + H2O + O2 = L-2-aminoadipate 6-semialdehyde + L-glutamate + H2O2
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
show the reaction diagram
-
L-saccharopine + H2O + O2 = L-2-aminoadipate 6-semialdehyde + L-glutamate + H2O2
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
exhibits noncompetitive inhibition against L-alpha-aminoadipate-delta-semialdehyde, L-glutamate, and NADPH
product inhibition, uncompetitive versus NADH

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (19 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
9.02
-
pH 8.0, 30°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2
-
-

References & Links

Links to other databases for saccharopine

ChEBI
PubChem
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PubChem