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Ligand 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 9 H4 2 N7 O1 8 P3 S
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
ZTMHVINYLDVBNO-FOGVYBFTSA-N
Show all BRENDA pathways known for 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA
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Substrate in Enzyme-catalyzed Reactions (2 results)
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epoxyphenylacetyl-CoA + O2 + NADPH + H+ = ?
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2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA
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Product in Enzyme-catalyzed Reactions (1 result)
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phenylacetyl-CoA + O2 + NADPH + H+ = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+
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Enzyme Kinetic Parameters
KM Value (1 result)
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0.006
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at pH 8.0 and 30°C
References & Links Literature References (3)
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Bacterial phenylalanine and phenylacetate catabolic pathway revealed
2010
Teufel, R.; Mascaraque, V.; Ismail, W.; Voss, M.; Perera, J.; Eisenreich, W.; Haehnel, W.; Fuchs, G.
Proc. Natl. Acad. Sci. USA
107
14390-14395
An oxygenase that forms and deoxygenates toxic epoxide
2012
Teufel, R.; Friedrich, T.; Fuchs, G.
Nature
483
359-362
Protein-protein interactions in the beta-oxidation part of the phenylacetate utilization pathway: crystal structure of the PaaF-PaaG hydratase-isomerase complex
2012
Grishin, A.M.; Ajamian, E.; Zhang, L.; Rouiller, I.; Bostina, M.; Cygler, M.
J. Biol. Chem.
287
37986-37996
Links to other databases for 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA