Ligand L-mimosine

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Basic Ligand Information

Molecular Structure
Picture of L-mimosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H10N2O4
L-mimosine
WZNJWVWKTVETCG-YFKPBYRVSA-N
Synonyms:
(S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate, 3-(3,4-dihydroxypyridin-1-yl)-L-alanine, 3-(3-hydroxy-4-oxo-1(4H)-pyridyl)-L-alanine, mimosine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O3-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
mimosine + H2O2 = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
50 mg/kg/day for 2 weeks
-
inhibits SHMT1 transcription by chelating zinc, eliminates the metal regulatory element- and Sp1-binding activity in nuclear extracts from MCF-7 cells, but not in nuclear extracts from the mimosine-resistant cell line, MCF-7/2a
-
weak
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
12180
-
pH 8.5, 37°C, recombinant enzyme

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.95
-
pH 8.5, 37°C, recombinant enzyme

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0477
-
with dopamine as a substrate

IC50 Value (5 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.00368
-
IC50: 0.00368 mM

References & Links

Links to other databases for L-mimosine

ChEBI
PubChem
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PubChem