Ligand aldosterone

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Basic Ligand Information

Molecular Structure
Picture of aldosterone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H28O5
aldosterone
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
Synonyms:
4-pregnene-18-al-11beta,21-diol-3,20-dione, aldosterone hemiacetal, d-aldosterone

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
aldosterone + NADPH = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Aldosterone + NADPH + O2 = ?
show the reaction diagram
-
UDP-glucuronate + aldosterone = UDP + aldosterone beta-D-glucuronide
show the reaction diagram
-
3'-phosphoadenylylsulfate + aldosterone = adenosine 3',5'-bisphosphate + aldosterone sulfate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
increased aldosterone levels lead to enhanced kallikrein activity
-
control of Na,K-ATPase activity and expression
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
i.e. aldosteron
-
diminishes GC activity by activating NADPH oxidase in bovine aortic VSMC to increase ROS levels and induce oxidative posttranslational modification of Cys122, a beta1-subunit cysteinyl residue
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.15
-
pH 6.0, 37°C
0.133
-
pH 7.5, 37°C

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0025
-
pH 6.0, 37°C
0.17
-
pH 7.5, 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.022
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C

References & Links

Links to other databases for aldosterone

ChEBI
PubChem
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PubChem