Ligand aldosterone

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Basic Ligand Information

Molecular Structure
Picture of aldosterone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H28O5
aldosterone
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
Synonyms:
4-pregnene-18-al-11beta,21-diol-3,20-dione, aldosterone hemiacetal, d-aldosterone

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
aldosterone + NADPH = ?
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
Aldosterone + NADPH + O2 = ?
-
show the reaction diagram
UDP-glucuronate + aldosterone = UDP + aldosterone beta-D-glucuronide
-
show the reaction diagram
3'-phosphoadenylyl sulfate + aldosterone = adenosine 3',5'-bisphosphate + ?
-
show the reaction diagram
3'-phosphoadenylylsulfate + aldosterone = adenosine 3',5'-bisphosphate + aldosterone sulfate
-

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (3 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (6 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
i.e. aldosteron
-
11-beta-HSD2, 50% inhibition at 0.000005 mM
-
sensitive
-
at an early time point (2 h) downregulates the steady-state level of mDot1a mRNA and this precedes, and is associated with, downregulation of histone H3 K79 methylation in mIMCD3 cells
-
diminishes GC activity by activating NADPH oxidase in bovine aortic VSMC to increase ROS levels and induce oxidative posttranslational modification of Cys122, a beta1-subunit cysteinyl residue
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
pH 6.0, 37°C
0.15
-
pH 7.5, 37°C
0.133
-

KM Value (4 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
pH 6.0, 37°C
0.0025
-
isozyme UGT2B7H268, pH 7.5, 37°C
0.00076
-
isozyme UGT2B7Y268, pH 7.5, 37°C
0.00036
-
pH 7.5, 37°C
0.17
-

IC50 Value (1 result)

COMMENTARY
EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
LITERATURE
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.022
-

References & Links

Links to other databases for aldosterone

ChEBI
PubChem
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PubChem