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Ligand aldosterone

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for aldosterone

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.3

aldosterone + NADPH = ?

390597

-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

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Show Natural Product (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.15.4

18-hydroxy-corticosterone + reduced adrenal ferredoxin + O2 = aldosterone + oxidized adrenal ferredoxin + H2O

285401

-

1.14.15.4

18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 = aldosterone + oxidized adrenal ferredoxin + H2O

0

-

1.14.15.4

18-hydroxycorticosterone + reduced adrenodoxin + O2 = aldosterone + oxidized adrenodoxin + H2O

0

-

1.14.15.4

18-hydroxycorticosterone + reduced ferredoxin + O2 = aldosterone + ferredoxin + H2O

0

-

1.14.15.4

4 entries

Substrate in Enzyme-catalyzed Reactions (6 results)

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Show Substrate (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.13.54

Aldosterone + NADPH + O2 = ?

7390

-

1.3.1.3

aldosterone + NADPH + H+ = ?

726492

-

1.3.1.3

aldosterone + NADPH = ?

390596, 390597

-

1.3.1.3

2 entries

2.4.1.17

UDP-glucuronate + aldosterone = UDP + aldosterone beta-D-glucuronide

658558

-

2.8.2.15

3'-phosphoadenylyl sulfate + aldosterone = adenosine 3',5'-bisphosphate + ?

760621

-

2.8.2.2

3'-phosphoadenylylsulfate + aldosterone = adenosine 3',5'-bisphosphate + aldosterone sulfate

645774, 645776

-

Product in Enzyme-catalyzed Reactions (6 results)

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Show Product (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.15.4

11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2 = aldosterone + oxidized adrenal ferredoxin + 2 H2O

285395, 285396, 285392, 285397, 285399, 285400, 285403

-

1.14.15.4

18-hydroxy-corticosterone + reduced adrenal ferredoxin + O2 = aldosterone + oxidized adrenal ferredoxin + H2O

285401

-

1.14.15.4

18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 = aldosterone + oxidized adrenal ferredoxin + H2O

0, 285398, 285402, 285401

-

1.14.15.4

18-hydroxycorticosterone + reduced adrenodoxin + O2 = aldosterone + oxidized adrenodoxin + H2O

0

-

1.14.15.4

18-hydroxycorticosterone + reduced ferredoxin + O2 = aldosterone + ferredoxin + H2O

0

-

1.14.15.4

corticosterone + reduced adrenal ferredoxin + O2 = aldosterone + oxidized adrenal ferredoxin + H2O

285404, 285395

-

1.14.15.4

6 entries

Activator in Enzyme-catalyzed Reactions (3 results)

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Show Activating Compound (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.3.1

-

488073

-

3.4.21.35

increased aldosterone levels lead to enhanced kallikrein activity

682101

-

7.2.2.13

control of Na,K-ATPase activity and expression

677134

-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

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Show Inhibitors (6 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.21

i.e. aldosteron

695881

-

1.1.1.B40

11-beta-HSD2, 50% inhibition at 0.000005 mM

285949

-

1.1.1.B40

sensitive

285950

-

2.1.1.360

-

671225

-

2.1.1.360

at an early time point (2 h) downregulates the steady-state level of mDot1a mRNA and this precedes, and is associated with, downregulation of histone H3 K79 methylation in mIMCD3 cells

671225

-

1.1.1.B40

2 entries

2.1.1.360

2 entries

4.6.1.2

diminishes GC activity by activating NADPH oxidase in bovine aortic VSMC to increase ROS levels and induce oxidative posttranslational modification of Cys122, a beta1-subunit cysteinyl residue

693256

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.3.1.3

0.15

-

pH 6.0, 37°C

726492

2.8.2.2

0.133

-

pH 7.5, 37°C

645774

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.3.1.3

0.0025

-

pH 6.0, 37°C

726492

2.4.1.17

0.00036

-

isozyme UGT2B7Y268, pH 7.5, 37°C

658558

2.4.1.17

0.00076

-

isozyme UGT2B7H268, pH 7.5, 37°C

658558

2.4.1.17

2 entries

2.8.2.2

0.17

-

pH 7.5, 37°C

645774

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.1.1.21

0.022

-

in 0.1 M potassium phosphate, pH 7.4, at 25°C

695881

References & Links

Literature References (27)

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Show Reference (27 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

7390

3486863

Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Purification and characterization

1986

Itagaki, E.

J. Biochem.

99

815-824

285392

2738055

Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex

1989

Ogishima, T.; Mitani, F.; Ishimura, Y.

J. Biol. Chem.

264

10935-10938

285395

3485096

The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11beta-, 18-hydroxylation, and aldehyde synthesis

1986

Yanigabashi, K.; Haniu, M.; Shively, J.E.; Shen, W.H.; Hall, P.

J. Biol. Chem.

261

3556-3562

285396

2788159

Isolation of two distinct cytochromes P-45011beta with aldosterone synthase activity from bovine adrenocortical mitochondria

1989

Ogishima, T.; Mitani, F.; Ishimura, Y

J. Biochem.

105

497-499

285397

2789017

Purification and characterization of two distinct forms of rat adrenal cytochrome P450(11) beta: functional and structural aspects

1989

Lauber, M.; Muller, J.

Arch. Biochem. Biophys.

274

109-119

285398

2337351

Lipid regulation of bovine cytochrome P45011beta activity

1990

Seybert, D.

Arch. Biochem. Biophys.

279

188-194

285399

2176837

Active site of bovine adrenocortical cytochrome P-45011beta studied by resonance Raman and electron paramagnetic resonance spectroscopies: distinction from cytochrome P-450scc

1990

Tsubaki, M.; Ichikawa, Y.; Fujimoto, Y.; Yu, N.T.; Hori, H.

Biochemistry

29

8805-8812

285400

2390091

Ascorbate as a source of reducing equivalents for the synthesis of aldosterone

1990

Yanigabashi, K.; Kobayashi, Y.; Hall, P.F.

Biochem. Biophys. Res. Commun.

170

1256-1262

285401

9430822

Functional and expression analysis of ovine steroid 11beta-hydroxylase (cytochrome P 45011beta)

1997

Boon, W.C.; Roche, P.J.; Butkus, A.; McDougall, J.G.; Jeyaseelan, K.; Coghlan, J.P.

Endocr. Res.

23

325-347

285402

7556158

Inhibition of bovine cytochrome P-45011beta by 18-unsaturated progesterone derivatives

1995

Delorme, C.; Piffeteau, A.; Viger, A.; Marquet, A.

Eur. J. Biochem.

232

247-256

285403

9310386

Mechanism-based inactivation of bovine cytochrome P-45011beta by 18-unsaturated progesterone derivatives

1997

Delorme, C.; Piffeteau, A.; Sobrio, F.; Marquet, A.

Eur. J. Biochem.

248

252-260

285404

9839008

18-Vinyldeoxycorticosterone: a potent inhibitor of the bovine cytochrome P-45011beta

1998

Davioud, E.; Piffeteau, A.; Delorme, C.; Coustal, S.; Marquet, A.

Bioorg. Med. Chem.

6

1781-1788

285949

8967481

Substrate and inhibitor specificity of the clones human 11beta-hydroxysteroid dehydrogenase type 2 isoform

1996

Ferrari, P.; Smith, R.E.; Funder, J.W.; Krozowski, Z.S.

Am. J. Physiol.

270

E900-904

285950

7727521

Characteristics and regulation of 11beta-hydroxysteroid dehydrogenase of proximal and distal nephron

1995

Alfaidy, N.; Blot-Chabaud, M.; Robic, D.; Kenouch, S.; Bourbouze, R.; Bonvalet, J.P.; Farman, N.

Biochim. Biophys. Acta

1243

461-468

390596

4149531

Studies on partially purified pig liver steroid DELTA4-5beta-reductase activity

1973

Van Doorn, E.J.; Nduaguba, J.C.; Clark, A.F.

Can. J. Biochem.

51

1661-1668

390597

11342103

Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme

2001

Charbonneau, A.; The, V.L.

Biochim. Biophys. Acta

1517

228-235

488073

10775554

Role of citrate synthase in aldosterone-mediated sodium reabsorption

2000

Ullian, M.E.; Robinson, C.J.; Evans, C.T.; Melnick, J.Z.; Fitzgibbon, W.R.

Hypertension

35

875-879

645774

6935986

The identity of alcohol sulfotransferases with hydroxysteroid sulfotransferases

1980

Lyon, E.S.; Jakoby, W.B.

Arch. Biochem. Biophys.

202

474-481

645776

6173569

Hydroxysteroid sulfotransferase

1981

Lyon, E.S.; Marcus, C.J.; Wang, J.L.; Jakoby, W.B.

Methods Enzymol.

77

206-213

658558

12746330

Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites

2003

Girard, C.; Barbier, O.; Veilleux, G.; El-Alfy, M.; Belanger, A.

Endocrinology

144

2659-2668

671225

16236820

Aldosterone-sensitive repression of ENaCalpha transcription by a histone H3 lysine-79 methyltransferase

2006

Zhang, W.; Xia, X.; Jalal, D.I.; Kuncewicz, T.; Xu, W.; Lesage, G.D.; Kone, B.C.

Am. J. Physiol. Cell Physiol.

290

C936-C946

677134

16139686

Hormonal and nonhormonal mechanisms of regulation of the NA,K-pump in collecting duct principal cells

2005

Vinciguerra, M.; Mordasini, D.; Vandewalle, A.; Feraille, E.

Semin. Nephrol.

25

312-321

682101

18311071

Urinary kallikrein and blood pressure - gender-different response to potassium supplementation in SHR. Role of aldosterone

2008

Oddo, E.M.; De Luca Sarobe, V.; Krmar, R.; Martin, R.S.; Ibarra, F.R.; Arrizurieta, E.E.

Nephron. Physiol.

108

p37-p45

693256

19141618

Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells

2009

Maron, B.A.; Zhang, Y.Y.; Handy, D.E.; Beuve, A.; Tang, S.S.; Loscalzo, J.; Leopold, J.A.

J. Biol. Chem.

284

7665-7672

695881

19464995

Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids

2009

Endo, S.; Matsunaga, T.; Mamiya, H.; Ohta, C.; Soda, M.; Kitade, Y.; Tajima, K.; Zhao, H.T.; El-Kabbani, O.; Hara, A.

Arch. Biochem. Biophys.

487

1-9

726492

21255593

Substrate specificity and inhibitor analyses of human steroid 5beta-reductase (AKR1D1)

2011

Chen, M.; Drury, J.E.; Penning, T.M.

Steroids

76

484-490

760621

28782626

DELTA4-3-ketosteroids as a new class of substrates for the cytosolic sulfotransferases

2017

Hashiguchi, T.; Kurogi, K.; Shimohira, T.; Teramoto, T.; Liu, M.C.; Suiko, M.; Sakakibara, Y.

Biochim. Biophys. Acta

1861

2883-2890

Links to other databases for aldosterone

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Show Links (1 entry)

ChEBI

PubChem