Ligand 17alpha-hydroxypregnenolone

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Basic Ligand Information

Molecular Structure
Picture of 17alpha-hydroxypregnenolone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H32O3
17alpha-hydroxypregnenolone
JERGUCIJOXJXHF-TVWVXWENSA-N
Synonyms:
(3beta,17alpha)-3,17-dihydroxypregn-5-en-20-one, 3beta,17alpha-dihydroxy-5-pregen-20-one, 3beta,17alpha-dihydroxy-5-pregnen-20-one, 3beta,17alpha-dihydroxy-pregn-5-ene-20-one, 3beta,17alpha-dihydroxypregn-5-en-20-one, 17-alpha-hydroxypregnenolone, 17-hydroxy-pregnenolone, 17-hydroxypregnenolone


Show all pahtways known for Show all BRENDA pathways known for 17alpha-hydroxypregnenolone

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
17alpha-hydroxypregnenolone + NAD+ = 17alpha-hydroxy-pregn-5-en-3,20-dione + NADH
show the reaction diagram
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3'-phosphoadenylyl sulfate + 17alpha-hydroxypregnenolone = adenosine 3',5'-bisphosphate + 17alpha-hydroxypregnenolone sulfate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
17alpha-hydroxypregnenolone + NADPH = ? + NADP+
show the reaction diagram
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17alpha-hydroxypregnenolone + NADH + H+ = 17alpha-hydroxyprogesterone + NAD+
show the reaction diagram
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17alpha-hydroxypregnenolone + NAD(P)+ = 17alpha-hydroxy-pregn-5-en-3,20-dione + NAD(P)H + H+
show the reaction diagram
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17alpha-hydroxypregnenolone + NADPH = 3beta,17alpha,20beta-trihydroxypregn-5-ene + NADP+
show the reaction diagram
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17alpha-hydroxypregnenolone + NADPH + O2 = ?
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Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3beta,17alpha,20alpha-trihydroxypregn-5-ene + NADP+ = 3beta,17alpha-dihydroxypregn-5-en-20-one + NADPH
show the reaction diagram
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cholesterol sulfate + reduced adrenodoxin + O2 = pregnenolone sulfate + 17-hydroxy-pregnenolone + dehydroisoandrosterone sulfate + oxidized adrenodoxin + H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition
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competitive inhibitor of 17alpha-hydrolase activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.00283
-
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KM Value (15 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.000897
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pH 7.7, 37°C

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 17alpha-hydroxypregnenolone

ChEBI
PubChem
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PubChem