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Ligand 1,6-anhydro-N-acetyl-beta-muramate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.170

ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetylmuramate 6-phosphate

738636, 738937, 738435

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Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.170

ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetyl-beta-muramate 6-phosphate + H+

715354, 715356, 715588

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2.7.1.170

ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetylmuramate 6-phosphate

738435, 738636, 738937

-

2.7.1.170

2 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.28

1,6-anhydro-N-acetylmuramic-acid-L-Ala-gamma-D-Glu-L-Lys + H2O = 1,6-anhydro-N-acetylmuramate + L-Ala-gamma-D-Glu-L-Lys

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Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.7.1.170

7000

-

pH and temperature not specified in the publication

738435

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.170

0.2

-

in 50 mM HEPES, pH 7.5, 10 mM MgCl2, and 50 mM KCl, at 37°C

715588

2.7.1.170

0.2

-

pH and temperature not specified in the publication

738435

2.7.1.170

1

-

in 100 mM Tris-HCl (pH 7.5), 20 mM MgCl2, at 37°C

715354

2.7.1.170

1

-

pH and temperature not specified in the publication

738435

2.7.1.170

4 entries

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

715354

15901686

Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate

2005

Uehara, T.; Suefuji, K.; Valbuena, N.; Meehan, B.; Donegan, M.; Park, J.T.

J. Bacteriol.

187

3643-3649

715356

16452451

MurQ etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall

2006

Uehara, T.; Suefuji, K.; Jaeger, T.; Mayer, C.; Park, J.T.

J. Bacteriol.

188

1660-1662

715588

21288904

Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase

2011

Bacik, J.P.; Whitworth, G.E.; Stubbs, K.A.; Yadav, A.K.; Martin, D.R.; Bailey-Elkin, B.A.; Vocadlo, D.J.; Mark, B.L.

J. Biol. Chem.

286

12283-12291

738435

27416973

Bioconversion of anhydrosugars: emerging concepts and strategies

2016

Bacik, J.P.; Jarboe, L.R.

IUBMB Life

68

700-708

738636

24362022

Conformational itinerary of Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase during its catalytic cycle

2014

Bacik, J.P.; Tavassoli, M.; Patel, T.R.; McKenna, S.A.; Vocadlo, D.J.; Khajehpour, M.; Mark, B.L.

J. Biol. Chem.

289

4504-4514

738937

25979372

Computational analysis of AnmK-like kinase: New insights into the cell wall metabolism of fungi

2015

Dai, J.; Qu, H.; Yu, Z.; Yang, J.; Zhang, H.

J. Theor. Biol.

379

59-65

Links to other databases for 1,6-anhydro-N-acetyl-beta-muramate

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Show Links (1 entry)

ChEBI

PubChem

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