Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Purification of prostaglandin E2-9-oxoreductase from human decidua vera
1984
Schlegel, W.; Kruger, S.; Korte, K.
FEBS Lett.
171
141-144
Enzymic properties of mouse 25-hydroxyvitamin D3 1alpha-hydroxylase expressed in Escherichia coli
1999
Sakaki, T.; Sawada, N.; Takeyama, K.i.; Kato, S.; Inouye, K.
Eur. J. Biochem.
259
731-738
Enzymatic studies on the key enzymes of vitamin D metabolism; 1alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24)
2001
Inouye, K.; Sakaki, T.
Biotechnol. Annu. Rev.
7
179-194
Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity
2002
Yamauchi, K.; Nakajima, J.
Eur. J. Biochem.
269
2257-2264
Estrogen metabolism in human colorectal cancer cells
2002
Fiorelli, G.; Picariello, L.; Martineti, V.; Tognarini, I.; Tonelli, F.; Brandi, M.L.
J. Steroid Biochem. Mol. Biol.
81
281-289
Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin
2007
Seo, Y.K.; Chung, Y.T.; Kim, S.; Echchgadda, I.; Song, C.S.; Chatterjee, B.
Gene
386
218-223
Regulatory properties of adenylate cyclases type 5 and 6: A progress report
2006
Beazely, M.A.; Watts, V.J.
Eur. J. Pharmacol.
535
1-12
Rapid identification of P-glycoprotein substrates and inhibitors
2006
Chang, C.; Bahadduri, P.M.; Polli, J.E.; Swaan, P.W.; Ekins, S.
Drug Metab. Dispos.
34
1976-1984
Wnt and steroid pathways control glutamate signalling by regulating glutamine synthetase activity in osteoblastic cells
2008
Olkku, A.; Mahonen, A.
Bone
43
483-493
Crystallization and preliminary X-ray diffraction studies of vitamin D3 hydroxylase, a novel cytochrome P450 isolated from Pseudonocardia autotrophica
2009
Yasutake, Y.; Fujii, Y.; Cheon, W.K.; Arisawa, A.; Tamura, T.
Acta Crystallogr. Sect. F
65
372-375
Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc
2008
Tuckey, R.C.; Li, W.; Zjawiony, J.K.; Zmijewski, M.A.; Nguyen, M.N.; Sweatman, T.; Miller, D.; Slominski, A.
FEBS J.
275
2585-2596
Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin
2008
Tuckey, R.C.; Nguyen, M.N.; Slominski, A.
Int. J. Biochem. Cell Biol.
40
2619-2626
Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450
2011
Inarrea, P.; Casanova, A.; Alava, M.A.; Iturralde, M.; Cadenas, E.
Free Radic. Biol. Med.
50
1575-1581
Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase
2005
Rahmaniyan, M.; Patrick, K.; Bell, N.H.
Am. J. Physiol. Endocrinol. Metab.
288
E753-E760
Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase
1997
Postlind, H.; Axen, E.; Bergman, T.; Wikvall, K.
Biochem. Biophys. Res. Commun.
241
491-497
The importance of residues in substrate recognition site 3 for the catalytic function of CYP2D25 (vitamin D 25-hydroxylase)
2001
Hosseinpour, F.; Hidestrand, M.; Ingelman-Sundberg, M.; Wikvall, K.
Biochem. Biophys. Res. Commun.
288
1059-1063
Metabolism of vitamin D by human microsomal CYP2R1
2004
Shinkyo, R.; Sakaki, T.; Kamakura, M.; Ohta, M.; Inouye, K.
Biochem. Biophys. Res. Commun.
324
451-457
Purification, characterization, and directed evolution study of a vitamin D3 hydroxylase from Pseudonocardia autotrophica
2009
Fujii, Y.; Kabumoto, H.; Nishimura, K.; Fujii, T.; Yanai, S.; Takeda, K.; Tamura, N.; Arisawa, A.; Tamura, T.
Biochem. Biophys. Res. Commun.
385
170-175
25-Hydroxylation of 1 alpha-hydroxyvitamin D-3 in rat and human liver
1985
Saarem, K.; Pedersen, J.I.
Biochim. Biophys. Acta
840
117-126
Purification from pig kidney of a microsomal cytochrome P450 catalyzing 1 alpha-hydroxylation of 25-hydroxyvitamin D3
1995
Axen, E.
FEBS Lett.
375
277-279
Purification and characterization of vitamin D 25-hydroxylase from rat liver mitochondria
1988
Masumoto, O.; Ohyama, Y.; Okuda, K.
J. Biol. Chem.
263
14256-14260
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase
2003
Cheng, J.B.; Motola, D.L.; Mangelsdorf, D.J.; Russell, D.W.
J. Biol. Chem.
278
38084-38093
Identification of a novel rat microsomal vitamin D3 25-hydroxylase
2004
Yamasaki, T.; Izumi, S.; Ide, H.; Ohyama, Y.
J. Biol. Chem.
279
22848-22856
Structural analysis of CYP2R1 in complex with vitamin D3
2008
Strushkevich, N.; Usanov, S.A.; Plotnikov, A.N.; Jones, G.; Park, H.W.
J. Mol. Biol.
380
95-106
Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases
2006
Aiba, I.; Yamasaki, T.; Shinki, T.; Izumi, S.; Yamamoto, K.; Yamada, S.; Terato, H.; Ide, H.; Ohyama, Y.
Steroids
71
849-856
UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1
2013
Yasuda, K.; Endo, M.; Ikushiro, S.; Kamakura, M.; Ohta, M.; Sakaki, T.
Biochem. Biophys. Res. Commun.
434
311-315
1alpha,25-dihydroxyvitamin D3 modulates CYP2R1 gene expression in human oral squamous cell carcinoma tumor cells
2014
Sundaram, K.; Sambandam, Y.; Tsuruga, E.; Wagner, C.L.; Reddy, S.V.
Horm. Cancer
5
90-97
CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo
2013
Zhu, J.G.; Ochalek, J.T.; Kaufmann, M.; Jones, G.; Deluca, H.F.
Proc. Natl. Acad. Sci. USA
110
15650-15655
Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1
2004
Sawada, N.; Sakaki, T.; Yoneda, S.; Kusudo, T.; Shinkyo, R.; Ohta, M.; Inouye, K.
Biochem. Biophys. Res. Commun.
320
156-164
Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1
2016
Hayashi, K.; Yasuda, K.; Yogo, Y.; Takita, T.; Yasukawa, K.; Ohta, M.; Kamakura, M.; Ikushiro, S.; Sakaki, T.
Biochem. Biophys. Res. Commun.
473
853-858
Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1
2008
Hayashi, K.; Sugimoto, H.; Shinkyo, R.; Yamada, M.; Ikeda, S.; Ikushiro, S.; Kamakura, M.; Shiro, Y.; Sakaki, T.
Biochemistry
47
11964-11972
Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3
2008
Sugimoto, H.; Shinkyo, R.; Hayashi, K.; Yoneda, S.; Yamada, M.; Kamakura, M.; Ikushiro, S.; Shiro, Y.; Sakaki, T.
Biochemistry
47
4017-4027
Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis
2010
Hayashi, K.; Yasuda, K.; Sugimoto, H.; Ikushiro, S.; Kamakura, M.; Kittaka, A.; Horst, R.L.; Chen, T.C.; Ohta, M.; Shiro, Y.; Sakaki, T.
FEBS J.
277
3999-4009
-
Molecular determinants for selective C25-hydroxylation of vitamins D2 and D3 by fungal peroxygenases
2015
Lucas, F.; Babot, E.; Canellas, M.; Del Rio, J.; Kalum, L.; Ullrich, R.; Hofrichter, M.; Guallar, V.; Martinez, A.; Gutierrez, A.
Catal. Sci. Technol.
6
288-295
Regioselective hydroxylation of cholecalciferol, cholesterol and other sterol derivatives by steroid C25 dehydrogenase
2017
Rugor, A.; Tataruch, M.; Staron, J.; Dudzik, A.; Niedzialkowska, E.; Nowak, P.; Hogendorf, A.; Michalik-Zym, A.; Napruszewska, D.; Jarzebski, A.; Szymanska, K.; Bialas, W.; Szaleniec, M.
Appl. Microbiol. Biotechnol.
101
1163-1174
Regioselective hydroxylation of cholecalciferol, cholesterol and other sterol derivatives by steroid C25 dehydrogenase
2017
Rugor, A.; Tataruch, M.; Staron, J.; Dudzik, A.; Niedzialkowska, E.; Nowak, P.; Hogendorf, A.; Michalik-Zym, A.; Napruszewska, D.; Jarzebski, A.; Szymanska, K.; Bialas, W.; Szaleniec, M.
Appl. Microbiol. Biotechnol.
101
1163-1174
Genome-wide association study of circulating vitamin D levels
2010
Ahn, J.; Yu, K.; Stolzenberg-Solomon, R.; Simon, K.C.; McCullough, M.L.; Gallicchio, L.; Jacobs, E.J.; Ascherio, A.; Helzlsouer, K.; Jacobs, K.B.; Li, Q.; Weinstein, S.J.; Purdue, M.; Virtamo, J.; Horst, R.; Wheeler, W.; Chanock, S.; Hunter, D.J.; Hayes, R.B.; Kraft, P.; Albanes, D.
Hum. Mol. Genet.
19
2739-2745
Genome-wide association study of circulating vitamin D levels
2010
Ahn, J.; Yu, K.; Stolzenberg-Solomon, R.; Simon, K.C.; McCullough, M.L.; Gallicchio, L.; Jacobs, E.J.; Ascherio, A.; Helzlsouer, K.; Jacobs, K.B.; Li, Q.; Weinstein, S.J.; Purdue, M.; Virtamo, J.; Horst, R.; Wheeler, W.; Chanock, S.; Hunter, D.J.; Hayes, R.B.; Kraft, P.; Albanes, D.
Hum. Mol. Genet.
19
2739-2745
Four molybdenum-dependent steroid C-25 hydroxylases heterologous overproduction, role in steroid degradation, and application for 25-hydroxyvitamin D3 synthesis
2018
Jacoby, C.; Eipper, J.; Warnke, M.; Tiedt, O.; Mergelsberg, M.; Staerk, H.J.; Daus, B.; Martin-Moldes, Z.; Zamarro, M.T.; Diaz, E.; Boll, M.
mBio
9
e00694-18
Four molybdenum-dependent steroid C-25 hydroxylases heterologous overproduction, role in steroid degradation, and application for 25-hydroxyvitamin D3 synthesis
2018
Jacoby, C.; Eipper, J.; Warnke, M.; Tiedt, O.; Mergelsberg, M.; Staerk, H.J.; Daus, B.; Martin-Moldes, Z.; Zamarro, M.T.; Diaz, E.; Boll, M.
mBio
9
e00694-18
Sequestration and microsomal C-25 hydroxylation of [3H]-vitamin D3 by the rat liver
1985
Gascon-Barre, M.; Elbaz, H.; Therrien-Ferland, D.
Metabolism
34
244-250
Sequestration and microsomal C-25 hydroxylation of [3H]-vitamin D3 by the rat liver
1985
Gascon-Barre, M.; Elbaz, H.; Therrien-Ferland, D.
Metabolism
34
244-250
Bacterial steroid hydroxylases enzyme classes, their functions and comparison of their catalytic mechanisms
2018
Szaleniec, M.; Wojtkiewicz, A.M.; Bernhardt, R.; Borowski, T.; Donova, M.
Appl. Microbiol. Biotechnol.
102
8153-8171
Protein engineering of CYP105s for their industrial uses
2018
Yasuda, K.; Sugimoto, H.; Hayashi, K.; Takita, T.; Yasukawa, K.; Ohta, M.; Kamakura, M.; Ikushiro, S.; Shiro, Y.; Sakaki, T.
Biochim. Biophys. Acta
1866
23-31
Comparison of the stability of CYP105A1 and its variants engineered for production of active forms of vitamin D
2022
Takita, T.; Sakuma, H.; Ohashi, R.; Nilouyal, S.; Nemoto, S.; Wada, M.; Yogo, Y.; Yasuda, K.; Ikushiro, S.; Sakaki, T.; Yasukawa, K.
Biosci. Biotechnol. Biochem.
86
444-454
Electrocatalytic hydroxylation of sterols by steroid C25 dehydrogenase from Sterolibacterium denitrificans
2018
Kalimuthu, P.; Wojtkiewicz, A.M.; Szaleniec, M.; Bernhardt, P.V.
Chemistry
24
7710-7717
Two novel CYP2R1 mutations in a family with vitamin D-dependent rickets type 1b
2021
Ozden, A.; Doneray, H.; Turkyilmaz, A.
Endocrine
72
852-864
Obesity decreases hepatic 25-hydroxylase activity causing low serum 25-hydroxyvitamin D
2019
Roizen, J.D.; Long, C.; Casella, A.; OLear, L.; Caplan, I.; Lai, M.; Sasson, I.; Singh, R.; Makowski, A.J.; Simmons, R.; Levine, M.A.
J. Bone Miner. Res.
34
1068-1073
Differential frequency of CYP2R1 variants across populations reveals pathway selection for Vitamin D homeostasis
2020
Casella, A.; Long, C.; Zhou, J.; Lai, M.; O'Lear, L.; Caplan, I.; Levine, M.; Roizen, J.
J. Clin. Endocrinol. Metab.
105
1302-1315
Properties of purified CYP2R1 in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3
2018
Cheng, C.; Kim, T.; Jeayeng, S.; Slominski, A.; Tuckey, R.
J. Steroid Biochem. Mol. Biol.
177
59-69
CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites
2018
Tuckey, R.; Li, W.; Ma, D.; Cheng, C.; Wang, K.; Kim, T.; Jeayeng, S.; Slominski, A.
J. Steroid Biochem. Mol. Biol.
181
1-10
Obesity represses CYP2R1, the vitamin D 25-hydroxylase, in the liver and extrahepatic tissues
2020
Elkhwanky, M.S.; Kummu, O.; Piltonen, T.T.; Laru, J.; Morin-Papunen, L.; Mutikainen, M.; Tavi, P.; Hakkola, J.
JBMR Plus
4
e10397
Biochemical Characterization of the cytochrome P450 CYP107CB2 from Bacillus lehensis G1
2018
Ang, S.S.; Salleh, A.B.; Chor, L.T.; Normi, Y.M.; Tejo, B.A.; Rahman, M.B.A.; Fatima, M.A.
Protein J.
37
180-193
-
The activating enzymes of vitamin D metabolism (25- and 1alpha-hydroxylases)
2018
Jones, G.; Prosser, D.; Kaufmann, M.
Vitamin D (ed. Feldman D.)
1
57-79
Enhancing the production of physiologically active vitamin D3 by engineering the hydroxylase CYP105A1 and the electron transport chain
2022
Fu, B.; Ren, Q.; Ma, J.; Chen, Q.; Zhang, Q.; Yu, P.
World J. Microbiol. Biotechnol.
38
14
Show all BRENDA pathways known for calciol
close all tables 
open all tables
top
