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Ligand 2-O-(alpha-D-mannopyranosyl)-D-glycerate

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for 2-O-(alpha-D-mannopyranosyl)-D-glycerate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.195

[protein]-Npi-phospho-L-histidine + 2-O-alpha-mannosyl-D-glycerate [side 1] = [protein]-L-histidine + 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate [side 2]

715472

-

3.2.1.208

2-O-(alpha-D-mannopyranosyl)-D-glycerate + H2O = D-mannopyranose + D-glycerate

750442

-

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

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Show Natural Product (7 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.269

GDP-mannose + D-glycerate = 2-O-(alpha-D-mannopyranosyl)-D-glycerate + GDP

-

-

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZU6, 3D-view

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZUP, 3D-view

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZW7, 3D-view

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZWD, 3D-view

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZX4, 3D-view

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZX5, 3D-view

3.1.3.70

6 entries

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.195

[protein]-Npi-phospho-L-histidine + 2-O-alpha-mannosyl-D-glycerate [side 1] = [protein]-L-histidine + 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate [side 2]

715472

-

3.2.1.208

2-O-(alpha-D-mannopyranosyl)-D-glycerate + H2O = D-mannopyranose + D-glycerate

750442, 723506, 772446

-

Product in Enzyme-catalyzed Reactions (21 results)

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Show Product (21 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.269

GDP-alpha-D-mannose + D-glycerate = GDP + 2-O-(alpha-D-mannopyranosyl)-D-glycerate

-

-

2.4.1.269

GDP-mannose + D-glycerate = 2-O-(alpha-D-mannopyranosyl)-D-glycerate + GDP

-

-

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZU6, 3D-view

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZUP, 3D-view

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZW7, 3D-view

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZWD, 3D-view

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZX4, 3D-view

3.1.3.70

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

393092, -

3ZX5, 3D-view

3.1.3.70

2-(alpha-D-glucosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZU6, 3D-view

3.1.3.70

2-(alpha-D-glucosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZUP, 3D-view

3.1.3.70

2-(alpha-D-glucosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZW7, 3D-view

3.1.3.70

2-(alpha-D-glucosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZWD, 3D-view

3.1.3.70

2-(alpha-D-glucosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZX4, 3D-view

3.1.3.70

2-(alpha-D-glucosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZX5, 3D-view

3.1.3.70

2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-O-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZU6, 3D-view

3.1.3.70

2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-O-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZUP, 3D-view

3.1.3.70

2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-O-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZW7, 3D-view

3.1.3.70

2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-O-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZWD, 3D-view

3.1.3.70

2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-O-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZX4, 3D-view

3.1.3.70

2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-O-(alpha-D-mannosyl)-D-glycerate + phosphate

-

3ZX5, 3D-view

2.4.1.269

2 entries

3.1.3.70

18 entries

3.1.3.85

2-O-(alpha-D-mannopyranosyl)-3-phospho-D-glycerate + H2O = 2-O-(alpha-D-mannopyranosyl)-D-glycerate + phosphate

-

-

3D Structure of Enzyme-Ligand-Complex (PDB) (42 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (42 entries)

EC NUMBER

ENZYME 3D STRUCTURE

3.1.3.70

3ZU6, 3D-view

3.1.3.70

3ZUP, 3D-view

3.1.3.70

3ZW7, 3D-view

3.1.3.70

3ZWD, 3D-view

3.1.3.70

3ZX4, 3D-view

3.1.3.70

3ZX5, 3D-view

3.1.3.70

3ZU6, 3D-view

3.1.3.70

3ZUP, 3D-view

3.1.3.70

3ZW7, 3D-view

3.1.3.70

3ZWD, 3D-view

3.1.3.70

3ZX4, 3D-view

3.1.3.70

3ZX5, 3D-view

3.1.3.70

3ZU6, 3D-view

3.1.3.70

3ZUP, 3D-view

3.1.3.70

3ZW7, 3D-view

3.1.3.70

3ZWD, 3D-view

3.1.3.70

3ZX4, 3D-view

3.1.3.70

3ZX5, 3D-view

3.1.3.70

3ZU6, 3D-view

3.1.3.70

3ZUP, 3D-view

3.1.3.70

3ZW7, 3D-view

3.1.3.70

3ZWD, 3D-view

3.1.3.70

3ZX4, 3D-view

3.1.3.70

3ZX5, 3D-view

3.1.3.70

3ZU6, 3D-view

3.1.3.70

3ZUP, 3D-view

3.1.3.70

3ZW7, 3D-view

3.1.3.70

3ZWD, 3D-view

3.1.3.70

3ZX4, 3D-view

3.1.3.70

3ZX5, 3D-view

3.1.3.70

3ZU6, 3D-view

3.1.3.70

3ZUP, 3D-view

3.1.3.70

3ZW7, 3D-view

3.1.3.70

3ZWD, 3D-view

3.1.3.70

3ZX4, 3D-view

3.1.3.70

3ZX5, 3D-view

3.1.3.70

3ZU6, 3D-view

3.1.3.70

3ZUP, 3D-view

3.1.3.70

3ZW7, 3D-view

3.1.3.70

3ZWD, 3D-view

3.1.3.70

3ZX4, 3D-view

3.1.3.70

3ZX5, 3D-view

3.1.3.70

42 entries

Enzyme Kinetic Parameters

K_M Value (5 results)

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Show KM Value (5 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.195

0.01

-

apparent value, at pH 7.6, temperature not specified in the publication

715472

3.2.1.208

2.62

-

pH 4.5, 70°C

750442

3.2.1.208

6.37

-

pH 4.5, 50°C

750442

3.2.1.208

11.8

-

pH 6.0, 40°C

723506

3.2.1.208

21.4

-

pH 6.0, 25°C

723506

3.2.1.208

4 entries

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

393092

11562374

Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes

2001

Empadinhas, N.; Marugg, J.D.; Borges, N.; Santos, H.; Da Costa, M.S.

J. Biol. Chem.

276

43580-43588

715472

14645248

Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor

2004

Sampaio, M.; Chevance, F.; Dippel, R.; Eppler, T.; Schlegel, A.; Boos, W.; Lu, Y.; Rock, C.

J. Biol. Chem.

279

5537-5548

723506

23179444

The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate

2012

Nobre, A.; Empadinhas, N.; Nobre, M.; Lourenco, E.; Maycock, C.; Ventura, M.; Mingote, A.; da Costa, M.

Planta

237

891-901

750442

23273275

A new bacterial hydrolase specific for the compatible solutes alpha-D-mannopyranosyl-(1->2)-D-glycerate and alpha-D-glucopyranosyl-(1->2)-D-glycerate

2013

Alarico, S.; Empadinhas, N.; da Costa, M.

Enzyme Microb. Technol.

52

77-83

750442

23273275

A new bacterial hydrolase specific for the compatible solutes alpha-D-mannopyranosyl-(1->2)-D-glycerate and alpha-D-glucopyranosyl-(1->2)-D-glycerate

2013

Alarico, S.; Empadinhas, N.; da Costa, M.

Enzyme Microb. Technol.

52

77-83

750442

2 entries

772446

31316802

The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation

2019

Cereija, T.B.; Alarico, S.; Lourenco, E.C.; Manso, J.A.; Ventura, M.R.; Empadinhas, N.; Macedo-Ribeiro, S.; Pereira, P.J.B.

IUCrJ

6

572-585

Links to other databases for 2-O-(alpha-D-mannopyranosyl)-D-glycerate

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Show Links (1 entry)