Ligand tetrahydrofuran

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of tetrahydrofuran (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H8O
tetrahydrofuran
KWKUIRGQJJFUCG-LMKUSPAJSA-N

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tetrahydrofuran + H2O2 = 4-hydroxybutanal + H2O
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10% v/v, 6.7fold activation
-
activation
-
activates
-
2.9fold activation at 2.5% v/v
-
the activity is enhanced by addition of 5% (v/v) tetrahydrofuran
-
5% (v/v), increases activity with 2-nitrophenyl beta-D-galactopyranoside or 4-nitrophenyl beta-D-glucopyranoside
-

Inhibitor in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
20% v/v, complete inhibition
-
20% v/v, complete inhibition
-
in tetrhydrofuran the activity of the enzyme decreases to 30-34% of the original activity
-
51% inhibition at 10% (vol/vol)
-
5% (v/v), decreases activity with 4-nitrophenyl beta-D-galactopyranoside or 4-nitrophenyl beta-D-fucopyranoside
-
reduces the activity by 86% at 6.25% v/v
-
10% (v/v), about 95% inhibition
-
inhibitory at concentrations above 2 M
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
33
-
in potassium phosphate buffer (50 mM, pH 7.0), at 23C

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.1
-
in potassium phosphate buffer (50 mM, pH 7.0), at 23C

References & Links

Links to other databases for tetrahydrofuran

ChEBI
PubChem
-
PubChem