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BRENDA support

Ligand phosphonoacetic acid

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Basic Ligand Information

Molecular Structure
Picture of phosphonoacetic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H5O5P
phosphonoacetic acid
XUYJLQHKOGNDPB-UHFFFAOYSA-N
Synonyms:
Phosphonoacetate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphonoacetaldehyde + NAD+ + H2O = phosphonoacetate + NADH + H+
show the reaction diagram

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
orotidine 5'-phosphate + phosphonoacetic acid = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphonoacetaldehyde + NAD+ + H2O = phosphonoacetate + NADH + H+
show the reaction diagram

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate activation, mechanism, overview
-

Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive to carbamoyl phosphate
-
substrate inhibition at 25 mM and above
-
10 mM, 30% inhibition
-
competitive inhibition versus ATP, noncompetitive versus bicarbonate
-
inhibits ATP synthesis reaction from carbamoyl phosphate and ADP, and synthesis of 10-formyltetrahydrofolate
-

3D Structure of Enzyme-Ligand-Complex (PDB) (5 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.15
-
-
1.95
-
recombinant enzyme, pH 7.2, 37°C
0.15
-
pH 7.4, 37°C

References & Links

Links to other databases for phosphonoacetic acid

ChEBI
PubChem
ChEBI
PubChem