Any feedback?
Please rate this page
(ligand.php)
(0/150)

BRENDA support

Ligand phenoxymethylpenicillin

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of phenoxymethylpenicillin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C16H18N2O5S
phenoxymethylpenicillin
BPLBGHOLXOTWMN-MBNYWOFBSA-N
Synonyms:
penicilin V, Penicillin V

Related pathways

Pathway Source
Pathways
MetaCyc
penicillin G and penicillin V biosynthesis

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
penicillin V + 2-oxoglutarate + O2 = ?
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
penicillin V + H2O = 6-aminopenicillanic acid + phenoxyacetic acid
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phenoxyacetyl-CoA + isopenicillin N + H2O = CoA + penicillin V + L-2-aminohexanedioate
show the reaction diagram
-
-
6-aminopenicillanic acid + phenoxyacetic acid = penicillin V + H2O
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
Pen V, is expected to cause competitive inhibition of BSH activity, but EfBSH shows enhanced activity towards glycodeoxycholic acid in the presence of Pen V, and no inhibition is observed, contrary to the expected results
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2.8 mM, 47% inhibition of the formation of deacetoxycephalosporin C
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (9 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
70.3
-
pH 8.0, 45°C

KM Value (15 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
13
-
-

References & Links

Links to other databases for phenoxymethylpenicillin

EXTERNAL LINKS