Ligand bathophenanthroline

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Basic Ligand Information

Molecular Structure
Picture of bathophenanthroline (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C24H16N2
bathophenanthroline
DHDHJYNTEFLIHY-UHFFFAOYSA-N
Synonyms:
1,10-bathophenanthroline

Roles as Enzyme Ligand

Inhibitor in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.02 mM, 97% inhibition
-
competitive vs. 6-methyl-5,6,7,8-tetrahydropterin and tetrahydrobiopterin, most probably due to chelation of enzyme's iron
-
0.5 mM, 71% inhibition
-
50% inhibition
-
slight
-
50% inhibition of hydroxylamine reductase 2 at 1 mM
-
inhibition of EutT
-
inhibition of AMP incorporating activity only, the CMP incorporating activity is much less sensitive
-
complete inhibition, activity fully restored by addition of Fe3+ at a ratio of 4 iron atoms to 1 mol inactive protein, the apoenzyme
-
a [4Fe-4S] cluster-containing protein activates 2-hydroxyisocaproyl-CoA dehydratase by an ATP-driven electron transfer. Iron chelation by bathophenanthroline removes the reduced [4Fe-4S] cluster from the activator protein in an ATP-dependent manner. With ADP, no chelation is observed. Chelation of the oxidised [4Fe-4S] cluster occurs faster with ADP than with ATP
-
96.2% inhibition at 10 mM
-

Enzyme Kinetic Parameters

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for bathophenanthroline

ChEBI
PubChem
ChEBI
PubChem