Ligand 6-Hydroxynicotinate

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Basic Ligand Information

Molecular Structure
Picture of 6-Hydroxynicotinate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H5NO3
6-Hydroxynicotinate
BLHCMGRVFXRYRN-UHFFFAOYSA-N
Synonyms:
2-Hydroxypyridine-5-carboxylate, 6-hydroxy-pyridine-3-carboxylate, 6-Hydroxynicotinic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin
show the reaction diagram
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nicotinic acid + acceptor = 6-hydroxynicotinic acid + reduced acceptor
show the reaction diagram
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nicotinic acid + acceptor + H2O = 6-hydroxynicotinic acid + reduced acceptor
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits effectively
-
tested at 1.0 mM, 12% inhibition
-
73% inhibition at 1 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.8
-
pH 7.5, 30°C

References & Links

Links to other databases for 6-Hydroxynicotinate

ChEBI
PubChem
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PubChem