Ligand 5-Aminopentanoate

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Basic Ligand Information

Molecular Structure
Picture of 5-Aminopentanoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H11NO2
5-Aminopentanoate
JJMDCOVWQOJGCB-UHFFFAOYSA-N
Synonyms:
5-amino-1-pentanoic acid, 5-Amino-n-pentanoate, 5-amino-n-pentanoic acid, 5-amino-n-valeric acid, 5-amino-pentanoic acid, 5-aminopentanoic acid, 5-amino pentanoic acid, 5-Aminovalerate, 5-Aminovaleric acid, delta-amino-n-valerate, Delta-Aminovalerate, delta-aminovaleric acid, Delta-NH2-n-Valeric acid


Show all pahtways known for Show all BRENDA pathways known for 5-Aminopentanoate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-aminopentanoate + 2-oxoglutarate = 5-oxovalerate + L-glutamate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-aminopentanamide + H2O = 5-aminopentanoate + NH3
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-aminovaleric acid + 2-oxoglutarate + O2 = D-2-hydroxy-5-aminovaleric acid + succinate + CO2
show the reaction diagram
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5-aminopentanoic acid + H2O + O2 = 5-oxopentanoate + NH3 + H2O2
show the reaction diagram
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Z-Gln-Gly + 5-aminovaleric acid = ?
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5-aminopentanoate + pyruvate = 5-oxopentanoate + L-alanine
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2-oxoglutarate + 5-aminopentanoate = glutamate + 5-oxopentanoate
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5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate
show the reaction diagram
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delta-amino-n-valerate + 4,5-dioxopentanoate = 5-aminolevulinate + 5-oxo-n-pentanoate
show the reaction diagram
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5-aminopentanoate + 2-oxoglutarate = 5-oxovalerate + L-glutamate
show the reaction diagram
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benzoyl-Arg ethyl ester + 5-amino-pentanoic acid = ethanol + benzoyl-Arg-5-amino-pentanoic acid
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ATP + L-His + 5-aminopentanoate = AMP + phosphate + 5-aminopentanoyl-L-His
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Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-aminovaleraldehyde + NAD+ + H2O = 5-aminovalerate + NADH + H+
show the reaction diagram
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5'-phospho-pyridoxyl-5-aminovalerate + H2O + O2 = pyridoxal 5'-phosphate + 5-aminovalerate + H2O2
show the reaction diagram
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N-carbamoyl-5-aminopentanoate + H2O = 5-aminopentanoate + CO2 + NH3
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5-acetamidopentanoate + H2O = acetate + 5-aminopentanoate
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5-guanidinovalerate + H2O = 5-aminopentanoate + urea
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5 mM, 1.65fold activation
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Inhibitor in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
36% inhibition at 5 mM
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competitive inhibition
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Ki: 4.1 mM
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competitive inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (29 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.9
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pH 8.0, 25°C, recombinant detagged enzyme
59
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0.0017
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pH 8, 37°C
4.1
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References & Links

Links to other databases for 5-Aminopentanoate

ChEBI
PubChem
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PubChem