Ligand 3-chloro-D-alanine

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Basic Ligand Information

Molecular Structure
Picture of 3-chloro-D-alanine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H6ClNO2
3-chloro-D-alanine
ASBJGPTTYPEMLP-UWTATZPHSA-N
Synonyms:
beta-Chloro-(S)-Ala, beta-chloro-(S)-alanine, beta-Chloro-D-alanine, beta-Cl-D-alanine, D-Chloroalanine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
beta-chloro-D-alanine + oxidized acceptor + H2O = ? + NH3 + reduced acceptor
show the reaction diagram
-
beta-Chloro-(S)-Ala + pyruvate + NADH = N-[1-(R)-(Carboxy)ethyl]-(S)-beta-chloroalanine + NAD+
show the reaction diagram
-
beta-chloro-D-alanine = pyruvate + ammonia + Cl-
show the reaction diagram
-
beta-chloro-D-alanine + H2O = ?
show the reaction diagram

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
beta-chloro-D-alanine = 3-chloro-D-alanine
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
18% inhibition of the O-acetyl-L-serine sulfhydrylation reaction
-

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (10 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
281
-
37°C, pH 8.0

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.19
-
pyruvate and NADH as cosubstrates
5.4
-
pH and temperature not specified in the publication

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 3-chloro-D-alanine

ChEBI
PubChem
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PubChem