Ligand (S)-reticuline

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Basic Ligand Information

Molecular Structure
Picture of (S)-reticuline (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H23NO4
(S)-reticuline
BHLYRWXGMIUIHG-HNNXBMFYSA-N

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 = (S)-corytuberine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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S-adenosyl-L-homocysteine + (S)-reticuline = S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine
show the reaction diagram
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S-adenosyl-L-homocysteine + (S)-reticuline = S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine
show the reaction diagram
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S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-laudanine
show the reaction diagram
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S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-tembetarine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-Adenosyl-L-homocysteine + (S)-reticuline
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-reticuline + 2-oxoglutarate + O2 = ?
show the reaction diagram
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(S)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 = (S)-corytuberine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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(S)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 = 1,2-dehydroreticuline + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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S-adenosyl-L-homocysteine + (S)-reticuline = S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine
show the reaction diagram
-
S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + codamine + laudanine
show the reaction diagram
-
S-adenosyl-L-homocysteine + (S)-reticuline = S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine
show the reaction diagram
-
S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-tembetarine
show the reaction diagram
-
S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-laudanine
show the reaction diagram
-
S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-tetrahydropapaverine
show the reaction diagram
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S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-tembetarine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-Adenosyl-L-homocysteine + (S)-reticuline
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (16 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.07
-
pH 8.0, 35°C
0.028
-
pH 7.0, 30°C

KM Value (10 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.016
-
pH 8.0, 35°C
0.042
-
pH 7.0, 30°C

References & Links

Links to other databases for (S)-reticuline

ChEBI
PubChem
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PubChem