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Ligand 4-aminomethylpyridine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.3.21

4-aminomethylpyridine + H2O + O2 = pyridine-4-carbaldehyde + NH3 + H2O2

724537

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1.4.3.22

4-aminomethylpyridine + H2O + O2 = 4-formylpyridine + NH3 + H2O2

688193

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Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.3.1

4-(ethylaminomethyl)pyridine + O2 + H2O = acetaldehyde + 4-(aminomethyl) pyridine + H2O2

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-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.4.3.13

-

741494

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2.1.1.53

-

485445

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Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (5 results)

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Show Turnover Number (5 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.4.3.21

3.1

-

in 50 mM Tris-HCl buffer, pH 8.0, at 25°C

724537

1.4.3.22

3

-

pH 7.2, 25°C

688193

1.4.3.22

3.72

-

pH 8.5, 25°C

688193

1.4.3.22

3.9

-

pH 7.2, 25°C

688193

1.4.3.22

4.46

-

pH 8.5, 25°C

688193

1.4.3.22

4 entries

K_M Value (5 results)

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Show KM Value (5 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.4.3.21

1.9

-

in 50 mM Tris-HCl buffer, pH 8.0, at 25°C

724537

1.4.3.22

0.1

-

pH 7.2, 25°C

688193

1.4.3.22

0.41

-

pH 7.2, 25°C

688193

1.4.3.22

0.45

-

pH 8.5, 25°C

688193

1.4.3.22

0.48

-

pH 8.5, 25°C

688193

1.4.3.22

4 entries

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.4.3.13

0.00122

-

LOXL2 protein, at pH 8.0 and 37°C

741494

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

485445

-

Purification and properties of putrescine N-methyltransferase from transformed roots of Datura stramonium L

1994

Walton, N.J.; Peerless, A.C.J.; Robins, R.J.; Rhodes, M.J.C.; Boswell, H.D.; Robins, D.J.

Planta

193

9-15

688193

17521737

Substrate specificity of copper-containing plant amine oxidases

2007

Pietrangeli, P.; Federico, R.; Mondovi, B.; Morpurgo, L.

J. Inorg. Biochem.

101

997-1004

724537

22901898

Molecular cloning and characterization of copper amine oxidase from Huperzia serrata

2012

Sun, J.; Morita, H.; Chen, G.; Noguchi, H.; Abe, I.

Bioorg. Med. Chem. Lett.

22

5784-5790

741494

28435530

Small molecule lysyl oxidase-like 2 (LOXL2) inhibitors the identification of an inhibitor selective for LOXL2 over LOX

2017

Hutchinson, J.H.; Rowbottom, M.W.; Lonergan, D.; Darlington, J.; Prodanovich, P.; King, C.D.; Evans, J.F.; Bain, G.

ACS Med. Chem. Lett.

8

423-427

741494

28435530

Small molecule lysyl oxidase-like 2 (LOXL2) inhibitors the identification of an inhibitor selective for LOXL2 over LOX

2017

Hutchinson, J.H.; Rowbottom, M.W.; Lonergan, D.; Darlington, J.; Prodanovich, P.; King, C.D.; Evans, J.F.; Bain, G.

ACS Med. Chem. Lett.

8

423-427

741494

2 entries

Links to other databases for 4-aminomethylpyridine

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Show Links (1 entry)