Ligand Polyphosphate

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Basic Ligand Information

Molecular Structure
Picture of Polyphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H6O15P5R
Polyphosphate
GZCGUPFRVQAUEE-JGWLITMVSA-N
Synonyms:
(Phosphate)n

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dolichyl diphosphate + (phosphate)n = dolichyl phosphate + (phosphate)n+1
show the reaction diagram
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(phosphate)n + H2O = (phosphate)n-1 + phosphate
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polyphosphate + H2O = ?
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In Vivo Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dolichyl diphosphate + (phosphate)n = dolichyl phosphate + (phosphate)n+1
show the reaction diagram
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NDP + polyphosphate = polyphosphate + NDP
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polyphosphate + H2O = ?
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polyphosphate + H2O = ?
show the reaction diagram
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polyphosphate + H2O = ?
show the reaction diagram
-
polyphosphate + H2O = oligophosphate
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polyphosphate + H2O = ?
show the reaction diagram
-
polyphosphate + H2O = ?
show the reaction diagram
-
polyphosphate + H2O = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NDP + polyphosphate = polyphosphate + NDP
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
dependent on, can be substituted by ATP, nonprocessive utilization, binding site is the same as for ATP binding
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activation of polyphosphate kinase 2
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PolyP, secreted by activated platelets, a highly anionic polymer, polyphosphate plus beta-thrombin accelerates plasma clotting and enhances thrombin generation, kinetics, overview. Thrombin binds with high affinity to immobilized polyphosphate. Polyphosphate accelerates factor XI autoactivation and factor XIa autolysis
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Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition above 5 mM
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substrate inhibition above 5 mM
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polyP15, 50% inhibition at 200fold polymer molar excess over the long-chain polyphosphate substrate
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.1
-
-
3.5
-
in the presence of Zn2+, pH 7.5, 25°C

KM Value (27 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.378
-
pH 4.8, 37°C
3.3
-
-
3.3
-
-
0.0000005
-
-
0.014
-
in the presence of Zn2+, pH 7.5, 25°C

References & Links

Links to other databases for Polyphosphate

ChEBI
PubChem
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PubChem