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BRENDA support

Ligand netilmicin

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Basic Ligand Information

Molecular Structure
Picture of netilmicin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H41N5O7
netilmicin
CIDUJQMULVCIBT-MQDUPKMGSA-N
Synonyms:
N-ethylsisomicin

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + N-ethylsisomicin = CoA + N3'-acetylethylsisomicin
show the reaction diagram
-
acetyl-CoA + netilmicin = CoA + N3'-acetylnetilmicin
show the reaction diagram
-
GTP + netilmicin = GDP + netilmicin 2''-phosphate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition of wild-type and mutant enzymes 1-3
-
substrate inhibition
-
80% inhibition at 0.01 mM, reversible by melanin
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (11 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
32
-
in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C

KM Value (15 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.042
-
in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.939
-
pH 8.0, 25°C
5.12
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.005
-
-

References & Links

Links to other databases for netilmicin

ChEBI
PubChem
-
PubChem