Ligand reduced acetylpyridine adenine dinucleotide

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Basic Ligand Information

Molecular Structure
Picture of reduced acetylpyridine adenine dinucleotide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C22H30N6O14P2
reduced acetylpyridine adenine dinucleotide
CIWXCGUGRDQCHH-RBEMOOQDSA-N
Synonyms:
3-acetyl-NADH, 3-acetylpyridine-adenine dinucleotide(H), 3-acetylpyridine-NADH, 3-acetylpyridine adenine dinucleotideH2, 3-acetylpyridine NADH, acetyl-NADH, acetylpyridine adenine nucleotide, reduced, APADH, reduced 3-acetylpyridin-adenine dinucleotide, reduced 3-acetylpyridine-adenine dinucleotide, reduced 3-acetylpyridine adenine dinucleotide, reduced 3-acetyl pyridine adenine dinucleotide, reduced acetyl pyridine adenine dinucleotide

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-malate + 3-acetylpyridine-adenine dinucleotide = oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+
show the reaction diagram
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NADPH + oxidized 3-acetylpyridine adenine dinucleotide = NADP+ + reduced 3-acetylpyridine adenine dinucleotide
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyruvate + APADH + H+ = (S)-lactate + APAD+
show the reaction diagram
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NADH + reduced 3-acetylpyridine adenine dinucleotide = NAD+ + oxidized 3-acetylpyridine adenine dinucleotide
show the reaction diagram
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orcinol + 3-acetylpyridine-NADH + H+ + O2 = 2,3,5-trihydroxytoluene + 3-acetylpyridine-NAD+ + H2O
show the reaction diagram
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7,8-dihydrofolate + acetylpyridine adenine nucleotide, reduced = 5,6,7,8-tetrahydrofolate + acetylpyridine adenine nucleotide, oxidized
show the reaction diagram
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trypanothione disulfide + reduced 3-acetylpyridine adenine dinucleotide = trypanothione + oxidized 3-acetylpyridine adenine dinucleotide
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (38 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
benzyl alcohol + oxidized 3-acetylpyridine adenine dinucleotide + H+ = benzaldehyde + reduced 3-acetylpyridine adenine dinucleotide
show the reaction diagram
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(R)-3-hydroxybutanoate + 3-acetylpyridine adenine dinucleotide = acetoacetate + 3-acetylpyridine adenine dinucleotideH2
show the reaction diagram
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isocitrate + APAD+ = 2-oxoglutarate + CO2 + APADH
show the reaction diagram
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xanthine + 3-acetylpyridine-adenine dinucleotide+ + H2O = urate + 3-acetylpyridine-adenine dinucleotide(H)
show the reaction diagram
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formate + 3-acetylpyridine-NAD+ = CO2 + 3-acetylpyridine-NADH
show the reaction diagram
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2-oxoglutarate + CoA + 3-acetylpyridine adenine dinucleotide = succinyl-CoA + CO2 + reduced 3-acetylpyridine adenine dinucleotide
show the reaction diagram
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succinate semialdehyde + 3-acetylpyridine adenine dinucleotide + H2O = succinate + reduced 3-acetylpyridine adenine dinucleotide + H+
show the reaction diagram
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propanal + 3-acetylpyridine-NAD+ + H2O = propionate + 3-acetylpyridine-NADH
show the reaction diagram
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D-malate + 3-acetylpyridine adenine dinucleotide = pyruvate + CO2 + reduced 3-acetylpyridine adenine dinucleotide
show the reaction diagram
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L-Ala + H2O + 3-acetylpyridine-NAD+ = pyruvate + H2O + 3-acetylpyridine-NADH
show the reaction diagram
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L-glutamate + 3-acetylpyridine-NAD+ = L-glutamine + 2-oxoglutarate + 3-acetylpyridine-NADH + H+
show the reaction diagram
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L-lysine + 3-acetylpyridine-NAD+ + H2O = alpha-aminoadipate delta-semialdehyde + NH3 + 3-acetylpyridine-NADH
show the reaction diagram
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L-Leu + H2O + 3-acetylpyridine-NAD+ = 4-methyl-2-oxopentanoate + NH3 + 3-acetylpyridine-NADH
show the reaction diagram
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NADPH + 3-acetylpyridine-NAD+ = NADP+ + 3-acetylpyridine-NADH
show the reaction diagram
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thioredoxin + 3-acetylpyridine adenine dinucleotide = thioredoxin disulfide + reduced 3-acetylpyridine adenine dinucleotide
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive vs. oxidized acetylpyridine dinucleotide, noncompetitive vs. NADPH
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0.02 mM, 52% residual activity in presence of 0.05 mM NAD, pH 7.4
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competitive inhibition vs. oxidized acetylpyridine adenine dinucleotide, mixed inhibition vs. NADPH
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (22 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.00386
-
pH 5.5, 25°C, recombinant enzyme
175
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pH 10.2

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0166
-
pH 5.5, 25°C, recombinant enzyme
0.37
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pH 10.2
0.00016
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25°C
0.65
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substrate: orcinol
0.004
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Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for reduced acetylpyridine adenine dinucleotide

ChEBI
PubChem
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PubChem